Admission glycemic variability correlates with in-hospital outcomes in diabetic patients with non-ST segment elevation acute coronary syndrome underwent percutaneous coronary intervention
| Autor: | Tao Zhang, Hong Tao, Hong-Xia Yang, Tao Wang, Shuhua Mi, Lei Tian, Wen-Long Dai, Gong Su |
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| Rok vydání: | 2018 |
| Předmět: |
Blood Glucose
Male China medicine.medical_specialty Acute coronary syndrome medicine.medical_treatment 030209 endocrinology & metabolism 030204 cardiovascular system & hematology 03 medical and health sciences Patient Admission Percutaneous Coronary Intervention 0302 clinical medicine Internal medicine Diabetes mellitus Outcome Assessment Health Care medicine Humans Myocardial infarction Non-ST Elevated Myocardial Infarction Glycemic business.industry Percutaneous coronary intervention Odds ratio Middle Aged Prognosis medicine.disease Treatment Outcome Diabetes Mellitus Type 2 Heart failure Conventional PCI Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Anatolian Journal of Cardiology. |
| ISSN: | 2149-2263 |
| Popis: | Objective The aim of this study is to evaluate the effects of admission glycemic variability (AGV) on in-hospital outcomes in diabetic patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS) undergoing percutaneous coronary intervention (PCI). Methods We studied 759 diabetic patients with NSTE-ACS undergoing PCI. AGV was accessed based on the mean amplitude of glycemic excursions (MAGEs) in the first 24 hours after admission. Primary outcome was a composite of in-hospital events, all-cause mortality, new-onset myocardial infarction, acute heart failure, and stroke. Secondary outcomes were each of these considered separately. Predictive effects of AGV on the in-hospital outcomes in patients were analyzed. Results Patients with high MAGE levels had significantly higher incidence of total outcomes (9.9% vs. 4.8%, p=0.009) and all-cause mortality (2.3% vs. 0.4%, p=0.023) than those with low MAGE levels during hospitalization. Multivariable analysis revealed that AGV was significantly associated with incidence of in-hospital outcomes (Odds ratio=2.024, 95% CI 1.105-3.704, p=0.022) but hemoglobin A1c (HbA1c) was not. In the receiver-operating characteristic curve analysis for MAGE and HbA1c in predicting in-hospital outcomes, the area under the curve for MAGE (0.608, p=0.012) was superior to that for HbA1c (0.556, p=0.193). Conclusion High AGV levels may be closely correlated with increased in-hospital poor outcomes in diabetic patients with NSTE-ACS following PCI. |
| Databáze: | OpenAIRE |
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