Hepatitis C Virus RNA Levels During Initial Induction or Standard Interferon Therapy: Influence of Continued Treatment on Sustained Response
| Autor: | Arvydas Ambrozaitis, Ola Weiland, Ligita Balciuniene, Olle Reichard, Tony Carlsson |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Microbiology (medical) Hepatitis C virus Hepacivirus Alpha interferon Interferon alpha-2 medicine.disease_cause Injections Intramuscular Drug Administration Schedule Statistics Nonparametric Virus chemistry.chemical_compound Interferon Humans Medicine Interferon alfa Aged Probability Retrospective Studies Dose-Response Relationship Drug General Immunology and Microbiology biology business.industry Ribavirin Remission Induction Interferon-alpha General Medicine Hepatitis C Chronic Middle Aged Viral Load biology.organism_classification Recombinant Proteins Treatment Outcome Infectious Diseases chemistry Immunology RNA Viral Female business Viral load Follow-Up Studies medicine.drug |
| Zdroj: | Scandinavian Journal of Infectious Diseases. 35:180-185 |
| ISSN: | 1651-1980 0036-5548 |
| DOI: | 10.1080/003655400310000175 |
| Popis: | Hepatitis C virus (HCV) RNA kinetics were studied at baseline weeks 4, 8 and 12 during interferon-alpha (IFN) monotherapy in 65 patients (mean age 39 y, range 19-66 y) with chronic HCV infection. IFN treatment was given either as initial induction (n = 34) or as standard dosing 3 times a week (n = 31). Patients with genotypes 2 and 3 had a significantly steeper decline in HCV RNA levels than patients with genotype 1 at weeks 4, 8 and 12 (p0.001 at all points measured). The decline in viral load was more pronounced in patients with induction therapy than with standard therapy at weeks 4, 8 and 12 (p0.02, 0.054 and 0.01, respectively). Patients with a sustained viral response had a 3-log decline in viral levels at week 4, with few exceptions. Two patients with non-response at week 12 (1 each with genotype 1 and non-1) responded after supplementation with ribavirin. |
| Databáze: | OpenAIRE |
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