Translational aspects of cardiac cell therapy
| Autor: | Cheng-Han Chen, Benjamin M. Wu, Konstantina-Ioanna Sereti, Reza Ardehali |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Biomedical
Cell- and Tissue-Based Therapy Myocardial Ischemia Review 030204 cardiovascular system & hematology Bioinformatics Cardiovascular Regenerative Medicine Cell therapy Translational Research Biomedical 0302 clinical medicine Myocyte Induced pluripotent stem cell Translational Medical Research 0303 health sciences cardiac regeneration 3. Good health medicine.anatomical_structure Heart Disease Molecular Medicine Stem Cell Research - Nonembryonic - Non-Human Development of treatments and therapeutic interventions Reprogramming Biotechnology biomaterials Cell type Biochemistry & Molecular Biology Clinical Trials and Supportive Activities Clinical Sciences 03 medical and health sciences Medicinal and Biomolecular Chemistry Clinical Research Translational Research medicine Humans Heart Disease - Coronary Heart Disease 030304 developmental biology 5.2 Cellular and gene therapies business.industry Regeneration (biology) Myocardium Mesenchymal stem cell cardiac progenitor cell Cell Biology Stem Cell Research direct reprogramming combination cell therapy Immunology Bone marrow Biochemistry and Cell Biology cell therapy business |
| Zdroj: | Journal of Cellular and Molecular Medicine Journal of cellular and molecular medicine, vol 19, iss 8 |
| ISSN: | 1582-4934 1582-1838 |
| Popis: | Cell therapy has been intensely studied for over a decade as a potential treatment for ischaemic heart disease. While initial trials using skeletal myoblasts, bone marrow cells and peripheral blood stem cells showed promise in improving cardiac function, benefits were found to be short-lived likely related to limited survival and engraftment of the delivered cells. The discovery of putative cardiac ‘progenitor’ cells as well as the creation of induced pluripotent stem cells has led to the delivery of cells potentially capable of electromechanical integration into existing tissue. An alternative strategy involving either direct reprogramming of endogenous cardiac fibroblasts or stimulation of resident cardiomyocytes to regenerate new myocytes can potentially overcome the limitations of exogenous cell delivery. Complimentary approaches utilizing combination cell therapy and bioengineering techniques may be necessary to provide the proper milieu for clinically significant regeneration. Clinical trials employing bone marrow cells, mesenchymal stem cells and cardiac progenitor cells have demonstrated safety of catheter based cell delivery, with suggestion of limited improvement in ventricular function and reduction in infarct size. Ongoing trials are investigating potential benefits to outcome such as morbidity and mortality. These and future trials will clarify the optimal cell types and delivery conditions for therapeutic effect. |
| Databáze: | OpenAIRE |
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