Serum ARCHITECT PIVKA-II reference interval in healthy Chinese adults: Sub-analysis from a prospective multicenter study
| Autor: | Yongfeng Yang, Zhuping Fan, Andrew Soh, Nianyue Wang, Jia Yang, Yijie Zheng, Huijun Li, Ping Liu, Jian Hu, Wei Chen, Xiaoqin Wang, Li Jiang, Ruilin Han, Guoyao Sang, Zhaoyun Chen, Wei Zhang, Feng Shen, Cunling Yan, Shu-Yang Dai, Agim Beshiri, Li Ma, Shunjun Li, Ying Huang, Lianhua Wei, Zhihui Li, Zhiyan Li, Tian Yang, Hao Xing |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty China Clinical Biochemistry Reference range Vitamin k 03 medical and health sciences 0302 clinical medicine Asian People Internal medicine medicine Chinese subjects Humans Prospective Studies Protein Precursors business.industry Significant difference Chinese adults General Medicine Middle Aged Reference intervals 030104 developmental biology Multicenter study 030220 oncology & carcinogenesis Biomarker (medicine) Female Prothrombin business Biomarkers |
| Zdroj: | Clinical biochemistry. 54 |
| ISSN: | 1873-2933 |
| Popis: | Protein induced by vitamin K absence or antagonist-II (PIVKA-II) has been widely used as a biomarker for liver cancer diagnosis in Japan for decades. However, the reference intervals for serum ARCHITECT PIVKA-II have not been established in the Chinese population. Thus, this study aimed to measure serum PIVKA-II levels in healthy Chinese subjects.This is a sub-analysis from the prospective, cross-sectional and multicenter study (ClinicalTrials.gov Identifier: NCT03047603). A total of 892 healthy participants (777 Han and 115 Uygur) with complete health checkup results were recruited from 7 regional centers in China. Serum PIVKA-II level was measured by ARCHITECT immunoassay. All 95% reference ranges were estimated by nonparametric method.The distribution of PIVKA-II values showed significant difference with ethnicity and sex, but not age. The 95% reference range of PIVKA-II was 13.62-40.38 mAU/ml in Han Chinese subjects and 15.16-53.74 mAU/ml in Uygur subjects. PIVKA-II level was significantly higher in males than in females (P 0.001). The 95% reference range of PIVKA-II was 15.39-42.01 mAU/ml in Han males while 11.96-39.13 mAU/ml in Han females.The reference interval of serum PIVKA-II on the Architect platform was established in healthy Chinese adults. This will be valuable for future clinical and laboratory studies performed using the Architect analyzer. Different ethnic backgrounds and analytical methods underline the need for redefining the reference interval of analytes such as PIVKA-II, in central laboratories in different countries. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect