Perenosins: a new class of anion transporter with anti-cancer activity

Autor:	Ali Tavassoli, Philip A. Gale, Daniel J. Asby, Wim Van Rossom
Rok vydání:	2016
Předmět:	Anions Models Molecular Benzimidazole Indoles Stereochemistry Cell Survival Imine 010402 general chemistry Crystallography X-Ray 01 natural sciences Biochemistry Antiporters chemistry.chemical_compound Structure-Activity Relationship Cell Line Tumor Humans Pyrroles Physical and Theoretical Chemistry Ion transporter Cell Proliferation Indole test Indazole Ion Transport Dose-Response Relationship Drug Molecular Structure 010405 organic chemistry Organic Chemistry Transporter Antineoplastic Agents Phytogenic 0104 chemical sciences chemistry MCF-7 Cells Imines Drug Screening Assays Antitumor Cotransporter
Zdroj:	Organicbiomolecular chemistry. 14(9)
ISSN:	1477-0539
Popis:	A new class of anion transporter named 'perenosins' consisting of a pyrrole linked through an imine to either an indole, benzimidazole or indazole is reported. The indole containing members of the perenosin family function as effective transmembrane Cl(-)/NO3(-) antiporters and HCl cotransporters in a manner similar to the prodigiosenes. The compounds reduce the viability of MDA-MB-231 and MCF-7.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794f1939f8cac587860a6416b8ff4362 https://pubmed.ncbi.nlm.nih.gov/26905059 Zobrazit plný text záznamu