Temporal changes in cerebral antioxidant enzyme activities after ischemia and reperfusion in a rat focal brain ischemia model: effect of dietary fish oil
| Autor: | Smi Choi-Kwon, Myoung Ae Choe, Kyung Ae Park, Myung-Sook Park, Joung Hee Lee, Sang Eun Jeon, Kyungchan Park, Hee Joo Lee |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Antioxidant medicine.medical_treatment Ischemia Biology Thiobarbituric Acid Reactive Substances Brain Ischemia Rats Sprague-Dawley Brain ischemia Fish Oils Developmental Neuroscience Internal medicine Image Processing Computer-Assisted medicine Animals chemistry.chemical_classification Glutathione Peroxidase Lipid peroxide Superoxide Dismutase Glutathione peroxidase Fatty Acids Brain Catalase Fish oil medicine.disease Eicosapentaenoic acid Rats Disease Models Animal Neuroprotective Agents Endocrinology chemistry Biochemistry Docosahexaenoic acid Reperfusion Injury Dietary Supplements Developmental Biology |
| Zdroj: | Developmental Brain Research. 152:11-18 |
| ISSN: | 0165-3806 |
| Popis: | This study investigated the neuroprotective effects of dietary supplementation of fish oil on both brain infarction and the activities of antioxidant enzymes. Male Sprague-Dawley rats (4-weeks old) were divided into two groups and received either a regular diet (RD) or a fish-oil-supplemented diet (FOD) for 6 weeks prior to middle cerebral artery (MCA) occlusion. The infarction volume of the brain was calculated using image analysis after staining. Antioxidant enzymes were measured before ischemia (BI), after 2 h of ischemia (AI) and after 24 h (24hR), 48 h (48hR) and after 7 days (7dR) of reperfusion. The infarction volume of the brain was significantly smaller in the FOD group than in the RD group after 24 h of reperfusion (p |
| Databáze: | OpenAIRE |
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