An injectable self-healing anesthetic glycolipid-based oleogel with antibiofilm and diabetic wound skin repair properties
| Autor: | Balasubramani Saritha, Yadavali Siva Prasad, Vellaisamy Sridharan, C. S. Srinandan, Sandeep Miryala, Subbiah Nagarajan, Krishnamoorthy Lalitha, C. Uma Maheswari |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
lcsh:Medicine 02 engineering and technology Pharmacology 010402 general chemistry medicine.disease_cause 01 natural sciences Skin Diseases Article Diabetes Mellitus Experimental chemistry.chemical_compound Glycolipid Nanoscience and technology medicine Animals Organic Chemicals Rats Wistar lcsh:Science Anesthetics Skin repair Wound Healing Multidisciplinary Bacteria Molecular medicine integumentary system Pseudomonas aeruginosa Antimicrobials lcsh:R Biofilm Health care Staphylococcal Infections 021001 nanoscience & nanotechnology Materials science 0104 chemical sciences Rats Chemistry chemistry Staphylococcus aureus Biofilms Anesthetic Curcumin Wound Infection Female lcsh:Q Glycolipids 0210 nano-technology Wound healing medicine.drug |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-73708-7 |
| Popis: | Globally, wound infections are considered as one of the major healthcare problems owing to the delayed healing process in diabetic patients and microbial contamination. Thus, the development of advanced materials for wound skin repair is of great research interest. Even though several biomaterials were identified as wound healing agents, gel-based scaffolds derived from either polymer or small molecules have displayed promising wound closure mechanism. Herein, for the first time, we report an injectable and self-healing self-assembled anesthetic oleogel derived from glycolipid, which exhibits antibiofilm and wound closure performance in diabetic rat. Glycolipid derived by the reaction of hydrophobic vinyl ester with α-chloralose in the presence of novozyme 435 undergoes spontaneous self-assembly in paraffin oil furnished an oleogel displaying self-healing behavior. In addition, we have prepared composite gel by encapsulating curcumin in the 3D fibrous network of oleogel. More interestingly, glycolipid in its native form demoed potential in disassembling methicillin-resistant Staphylococcus aureus, methicillin-susceptible Staphylococcus aureus, and Pseudomonas aeruginosa biofilms. Both oleogel and composite gel enhanced the wound skin repair in diabetic induced Wistar rats by promoting collagen synthesis, controlling free radical generation and further regulating tissue remodeling phases. Altogether, the reported supramolecular self-assembled anesthetic glycolipid could be potentially used for diabetic skin wound repair and to treat bacterial biofilm related infections. |
| Databáze: | OpenAIRE |
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