Dehydroepiandrosterone reduces cancellous bone osteopenia in ovariectomized rats
| Autor: | L. N. Parker, E. T. Lifrak, M. Beckner, G. K. Wakley, Kathleen S. Hannon, Russell T. Turner |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
genetic structures Physiology medicine.drug_class Endocrinology Diabetes and Metabolism Ovariectomy Dehydroepiandrosterone Osteoclasts Bone and Bones Reference Values Physiology (medical) Internal medicine medicine Animals Tibia Osteoblasts Chemistry Uterus food and beverages medicine.disease Androgen Rats Inbred F344 Rats Osteopenia Diaphysis Bone Diseases Metabolic medicine.anatomical_structure Endocrinology Delayed-Action Preparations Ovariectomized rat lipids (amino acids peptides and proteins) Cortical bone Female Cancellous bone |
| Zdroj: | The American journal of physiology. 258(4 Pt 1) |
| ISSN: | 0002-9513 |
| Popis: | The effects of dehydroepiandrosterone (DHA) on cortical bone at the tibial diaphysis and cancellous bone at the tibial metaphysis were determined in intact and ovariectomized rats. Total plasma DHA was reduced at 10 and 16 wk after ovariectomy. Intact and ovariectomized rats were implanted monthly with controlled-release subcutaneous pellets containing 2.5 mg of DHA or placebo. Plasma DHA was elevated in DHA-treated intact rats and was near normal in hormone-treated ovariectomized rats. Ovariectomy resulted in severe cancellous bone osteopenia, which was reduced in DHA-treated animals. Cross-sectional and cortical areas were increased at the diaphysis in ovariectomized rats, and this was not altered by DHA treatment. Bone formation at the endosteal and periosteal surfaces of the tibial diaphysis was decreased 16 wk after ovariectomy, and DHA treatment appeared to antagonize these changes. We interpret these results as evidence that decreased peripheral DHA levels contribute to the skeletal changes in ovariectomized rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|