CD80 and CD86 costimulatory molecules on circulating T cells of HIV infected individuals
| Autor: | Thomas Wendland, Roland Grunow, Christine Köchli, Werner J. Pichler, Karin Frutig, Steven Merlin |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes T-Lymphocytes Immunology HIV Infections chemical and pharmacologic phenomena HIV Envelope Protein gp120 Interleukin 21 CD28 Antigens Antigen Antigens CD Humans Immunology and Allergy Cytotoxic T cell Antigen-presenting cell CD86 Antigen Presentation Membrane Glycoproteins Chemistry CD28 hemic and immune systems HLA-DR Antigens Middle Aged B7-1 Antigen HIV-1 RNA Viral B7-2 Antigen CD80 CD8 |
| Zdroj: | Immunology Letters. 65:197-201 |
| ISSN: | 0165-2478 |
| DOI: | 10.1016/s0165-2478(98)00107-2 |
| Popis: | The expression of CD80 and CD86 costimulatory molecules, typical for antigen presenting cells (APC), was measured on circulating T cells of 20 HIV-infected individuals and of 11 HIV-negative healthy controls. The CD80 and CD86 molecules were present on both circulating T subsets of HIV-infected individuals (mean of CD80 expression within CD4+ T cells [CD80/CD4]: 5.0%; and CD86/CD4: 2.6%; CD80/CD8 4.1% and CD86/CD8: 2.7%) and were associated with HLA-DR expression. Some CD80 and CD86 expression was also found in normal controls, and only the expression of CD86 was significantly (P0.05) increased on CD4 + and CD8 + T cells of HIV-infected individuals. The expression of CD28 was decreased on T cells of HIV-infected individuals and was negatively correlated to the expression of HLA-DR and CD86 (mean CD28 within CD3+T cells: HIV+ 29.5%, HIV - 67.6%; correlation coefficient, - 0.75 and - 0.71, respectively). The more the disease proceeds, the less CD28 and the more DR and CD86 are found on circulating T cells. This suggests that during HIV infection T cells themselves develop an antigen presenting phenotype by upregulating expression of HLA-DR, CD86 and CD80 molecules. |
| Databáze: | OpenAIRE |
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