Efficacy of Tacrolimus/Mycophenolate Mofetil as Acute Graft-Versus-Host Disease Prophylaxis and the Impact of Subtherapeutic Tacrolimus Levels in Children after Matched Sibling Donor Allogeneic Hematopoietic Cell Transplantation

Autor:	Chalitha Robinson, Esra Karamehmet, Prakash Satwani, Diane George, Michelle Kolb, Andrew L. Kung, Zhezhen Jin, Katharine Offer, James Garvin, Jean Sosna, Monica Bhatia
Rok vydání:	2015
Předmět:	Adult Male medicine.medical_specialty Transplantation Conditioning Adolescent Tacrolimus level medicine.medical_treatment Graft vs Host Disease chemical and pharmacologic phenomena Hematopoietic stem cell transplantation Gastroenterology Disease-Free Survival Tacrolimus Mycophenolic acid Neoplasms Internal medicine medicine Humans Sibling Child Survival rate Retrospective Studies Transplantation Acute GVHD business.industry Siblings Hematopoietic Stem Cell Transplantation Infant Retrospective cohort study Hematology Mycophenolic Acid ROC curve Survival Rate surgical procedures operative Child Preschool Acute Disease Immunology Female business Immunosuppressive Agents medicine.drug
Zdroj:	Biology of Blood and Marrow Transplantation. 21(3):496-502
ISSN:	1083-8791
DOI:	10.1016/j.bbmt.2014.11.679
Popis:	Only a few studies in children have evaluated the efficacy of prophylactic regimens using tacrolimus on acute graft-versus-host disease (aGVHD). As a result, optimal tacrolimus levels in children after matched sibling donor allogeneic hematopoietic cell transplantation (alloHCT) are not well defined. We measured the association between subtherapeutic levels (
Databáze:	OpenAIRE
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