Retinol and α‐tocopherol in pregnancy: Establishment of reference intervals and associations with CBC

Autor: Guodong Tang, Youran Li, Yanhong Zhai, Ying Dong, Jingrui Liu, Lin Li, Sien Zhan, Zheng Cao, Ying Liu, Yan Jia
Rok vydání: 2020
Předmět:
0301 basic medicine
alpha-Tocopherol
Physiology
Hoffmann method
LC‐MS/MS
chemistry.chemical_compound
0302 clinical medicine
Pregnancy
Reference Values
Tandem Mass Spectrometry
030212 general & internal medicine
Tocopherol
Vitamin A
Prenatal vitamins
education.field_of_study
Nutrition and Dietetics
medicine.diagnostic_test
Incidence (epidemiology)
Retinol
Obstetrics and Gynecology
Complete blood count
Anemia
Vitamins
Micronutrient
Original Article
Female
maternal nutrition
retinol
Adult
Population
03 medical and health sciences
medicine
quantitative methods
Humans
education
anaemia
030109 nutrition & dietetics
business.industry
Public Health
Environmental and Occupational Health
Original Articles
reference interval
medicine.disease
α‐tocopherol
Blood Cell Count
nutritional status
chemistry
inflammation
Pediatrics
Perinatology and Child Health
business
Chromatography
Liquid
Zdroj: Maternal & Child Nutrition
ISSN: 1740-8709
1740-8695
DOI: 10.1111/mcn.12975
Popis: Profound physiological changes during pregnancy may affect the requirement of retinol and tocopherol, which are essential micronutrients for the maintenance of maternal health and foetal development. However, the current reference intervals (RIs) of retinol and tocopherol are based on non‐pregnant population. In the present study, a liquid chromatography–tandem mass spectrometry quantitation method for serum retinol and α‐tocopherol was established and validated. In addition, we established trimester‐specific RIs of retinol and α‐tocopherol using the data from paired screening test for 31,301 outpatients who participated in the prenatal vitamins A/E evaluation program at our hospital using the Hoffmann method, which is a simple indirect RI estimation method that does not require the recruitment of healthy subjects. Further, to explore the associations between the levels of retinol and α‐tocopherol and the parameters of complete blood count (CBC), the results of retinol, α‐tocopherol, and CBC of 1,977 pregnant outpatients in the third trimester were analysed. The testing interval between the levels of vitamins and CBC was no more than 7 days. Although no significant changes were noticed in the levels of retinol, the α‐tocopherol levels continuously increased with normal physiological changes throughout pregnancy. Lower retinol levels were associated with the higher incidence of anaemia, whereas higher levels of retinol and lower levels of α‐tocopherol were associated with higher platelet count.
Databáze: OpenAIRE
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