Novel colon cancer susceptibility variants identified from a genome‐wide association study in African Americans
| Autor: | Lynne R. Wilkens, Jane C. Figueiredo, Fredrick R. Schumacher, Mala Pande, Christopher A. Haiman, Krista A. Zanetti, Robert W. Haile, Ikuko Kato, Lisa B. Signorello, Sonja I. Berndt, David V. Conti, Temitope O. Keku, Terrilea Burnett, Polly A. Newcomb, Hansong Wang, Daniel O. Stram, Stephanie L. Schmit, Dee W. West, Loic Le Marchand, Curtis C. Harris, Julie R. Palmer, William J. Blot, David Van Den Berg |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Cancer Research Genotype Colorectal cancer Genome-wide association study Biology Polymorphism Single Nucleotide Article 03 medical and health sciences Asian People Gene Frequency Risk Factors medicine Humans Genetic Predisposition to Disease 1000 Genomes Project Allele Alleles Aged Genetic association Genetics Genetic diversity Nuclear Proteins Hispanic or Latino Odds ratio Middle Aged medicine.disease Confidence interval Black or African American 030104 developmental biology Oncology Colonic Neoplasms Female Chromosomes Human Pair 19 Genome-Wide Association Study |
| Zdroj: | International Journal of Cancer. 140:2728-2733 |
| ISSN: | 1097-0215 0020-7136 |
| DOI: | 10.1002/ijc.30687 |
| Popis: | Genome-wide association studies (GWAS) in ethnic/racial minority populations can help to fine-map previously identified risk regions or discover new risk loci because of the genetic diversity in these populations. We conducted a GWAS of colorectal cancer (CRC) in 6,597 African Americans (1,894 cases and 4,703 controls) (Stage 1) and followed up the most promising markers in a replication set of 2,041 participants of African descent (891 cases and 1,150 controls) (Stage 2). We identified a novel variant, rs56848936 in the gene SYMPK at 19q13.3, associated with colon cancer risk (odds ratio 0.61 for the risk allele G, p = 2.4 × 10-8 ). The frequency of the G allele was 0.06 in African Americans, compared to |
| Databáze: | OpenAIRE |
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