Thrombopoietin and mean platelet volume in coronary artery disease
| Autor: | Ertan Yetkin, Handan Şenaran, Mehmet Ileri, Şerafettin Kirazli, Mustafa Öztürk, Ahmet AltinbaŞ, YaŞar Karaaslan, Ali KoŞar |
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| Rok vydání: | 2001 |
| Předmět: |
Blood Platelets
Male medicine.medical_specialty Coronary Disease Coronary artery disease Risk Factors Internal medicine Statistical significance medicine Humans Platelet cardiovascular diseases Myocardial infarction Mean platelet volume Thrombopoietin Aged Platelet Count business.industry Unstable angina Articles General Medicine Venous blood Middle Aged medicine.disease Immunology Cardiology Female Cardiology and Cardiovascular Medicine business Megakaryocytes |
| Zdroj: | Clinical Cardiology. 24:405-408 |
| ISSN: | 1932-8737 0160-9289 |
| DOI: | 10.1002/clc.4960240511 |
| Popis: | Summary Bnckgmund: Large platelets are shown to be hemostatically more active. It has been suggested that mean platelet volume (MPV) is increased during acute myocardial infarction (AMI) and unstable angina pectoris (USAP). However, the underlying mechanism of the phenomenon remains unclear. Hypothesis: In this study, platelets, MPV, and thrombopoietin (TP) levels were investigated in patients with coronary artery disease (CAD) and healthy controls. Methods: Twenty patients with AM1 and 20 patients with USAP were included in this study. Seventeen healthy adult subjects served as controls. Venous blood samples of the subjects were drawn within 12 h after admission. Thrombopoietin levels were measured by ELISA and platelet counts and MPV were assayed by autoanalyzer. Results: Patients with AM1 and USAP had higher platelet counts than those in the control group. Although the platelet counts were slightly higher in AM1 than in USAP, this did not reach statistical significance. Mean platelet volume and levels of TP were found to be elevated in patients with AM1 and USAP compared with control subjects (p |
| Databáze: | OpenAIRE |
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