Human and mouse dopamine transporter genes: conservation of 5'-flanking sequence elements and gene structures
| Autor: | Elizabeth Nanthakumar, Roxann Ingersoll, David J. Vandenbergh, Geoffrey S. Bird, Michael P. Perry, David M. Donovan, George R. Uhl |
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| Rok vydání: | 1995 |
| Předmět: |
Neurotransmitter transporter
DNA Complementary Dopamine Plasma Membrane Transport Proteins Dopamine Molecular Sequence Data Gene Expression Nerve Tissue Proteins Biology Polymerase Chain Reaction Cellular and Molecular Neuroscience chemistry.chemical_compound Mice medicine Animals Humans RNA Messenger Neurotransmitter Promoter Regions Genetic Molecular Biology Gene Dopamine transporter Genetics Membrane Glycoproteins Base Sequence Dopaminergic Membrane Transport Proteins Transporter Blotting Northern nervous system chemistry biology.protein Carrier Proteins medicine.drug |
| Zdroj: | Brain research. Molecular brain research. 30(2) |
| ISSN: | 0169-328X |
| Popis: | Synaptic reaccumulation of the neurotransmitter dopamine is mediated by the dopamine transporter (DAT), a member of the family of twelve transmembrane domain, sodium- and chloride-dependent neurotransmitter transporters. Several DAT features, including its exclusive expression in dopaminergic neurons, implication in cocaine action, and prominent role in the mechanisms of Parkinsonism-inducing neurotoxins, make understanding of the DAT gene of interest. Isolation and characterization of the human and mouse DAT genes has allowed elucidation of similarities between each and other members of this transporter gene family. Sequences 5' to transcriptional start sites contain G-C rich, TATA-less, CAAT-less regions with striking conservation between human and mouse gene flanking regions. These studies suggest sequence elements that are candidates to contribute to the dopamine transporter's dopaminergic cell-specific expression. |
| Databáze: | OpenAIRE |
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