Protective effects of quercetin-loaded microcapsules on the enteric nervous system of diabetic rats
| Autor: | Jacqueline Nelisis Zanoni, Catchia Hermes-Uliana, Flávia Alessandra Guarnier, Camila Cavicchioli Sehaber-Sierakowski, Heber Amilcar Martins, Fernanda Paschoal Blegniski, Flávia Cristina Vieira-Frez, Marcela M. Baracat, Gleison Daion Piovezana Bossolani, Juliana Vanessa Colombo Martins Perles, Mariana Machado Lima |
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| Rok vydání: | 2020 |
| Předmět: |
Antioxidant
medicine.medical_treatment Population Capsules Pharmacology medicine.disease_cause Neuroprotection Enteric Nervous System Diabetes Mellitus Experimental 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Diabetes mellitus Nitrergic Neurons medicine Animals Rats Wistar education education.field_of_study Endocrine and Autonomic Systems medicine.disease Rats Oxidative Stress chemistry Enteric nervous system Quercetin Neurology (clinical) Nitrergic Neuron 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Autonomic neuroscience : basicclinical. 230 |
| ISSN: | 1872-7484 |
| Popis: | Quercetin-loaded microcapsules (QLM) promote controlled release and higher bioavailability of quercetin, an antioxidant and neuroprotective agent. We evaluated the antioxidant effect of QLM on enteric innervation and in the oxidative status of the ileum of diabetic rats. Wistar adult rats (Rattus norvegicus) were used in six groups containing normoglycemic (N), diabetic (D) and either normoglycemic or diabetic groups treated with QLM at a dose of 10 mg/kg (NQ10 and DQ10, respectively) or 100 mg/kg (NQ100 and DQ100, respectively). DQ10 e DQ100 did not prevent overall neuronal loss in the total and cholinergic populations. Nitrergic population showed differences regarding the treatments: DQ10 preserved neurons in the nitrergic population whilst DQ100 increased nitrergic loss. Evaluation of the redox status showed pro-oxidant effects in NQ100 by t-butyl-induced chemiluminescence analysis. We observed a reduction in the carbonylic content and an increase of low molecular weight antioxidants for DQ10 e DQ100. Therefore, QLM treatment at a dose of 10 mg/kg acted positively on nitrergic neurons reducing oxidative damage induced by diabetes. |
| Databáze: | OpenAIRE |
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