Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error
Autor: | Tedja, MS, Wojciechowski, R, Hysi, PG, Eriksson, N, Furlotte, NA, Verhoeven, VJM, Iglesias, AI, Meester-Smoor, MA, Tompson, SW, Fan, Q, Khawaja, AP, Cheng, C-Y, Höhn, R, Yamashiro, K, Wenocur, A, Grazal, C, Haller, T, Metspalu, A, Wedenoja, J, Jonas, JB, Wang, YX, Xie, J, Mitchell, P, Foster, PJ, Klein, BEK, Klein, R, Paterson, AD, Hosseini, SM, Shah, RL, Williams, C, Teo, YY, Tham, YC, Gupta, P, Zhao, W, Shi, Y, Saw, W-Y, Tai, E-S, Sim, XL, Huffman, JE, Polašek, O, Hayward, C, Bencic, G, Rudan, I, Wilson, JF, Consortium, Cream, Team, 23Andme Research, Consortium, Uk Biobank Eye And Vision, Joshi, PK, Tsujikawa, A, Matsuda, F, Whisenhunt, KN, Zeller, T, Van Der Spek, PJ, Haak, R, Meijers-Heijboer, H, Van Leeuwen, EM, Iyengar, SK, Lass, JH, Hofman, A, Rivadeneira, F, Uitterlinden, AG, Vingerling, JR, Lehtimäki, T, Raitakari, OT, Biino, G, Concas, MP, Schwantes-An, T-H, Igo, RP, Cuellar-Partida, G, Martin, NG, Craig, JE, Gharahkhani, P, Williams, KM, Nag, A, Rahi, JS, Cumberland, PM, Delcourt, C, Bellenguez, C, Ried, JS, Bergen, AA, Meitinger, T, Gieger, C, Wong, TY, Hewitt, AW, Mackey, DA, Simpson, CL, Pfeiffer, N, Pärssinen, O, Baird, PN, Vitart, V, Amin, N, Van Duijn, CM, Bailey-Wilson, JE, Young, TL, Saw, S-M, Stambolian, D, Macgregor, S, Guggenheim, JA, Tung, JY, Hammond, CJ, Klaver, CCW |
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Přispěvatelé: | Netherlands Institute for Neuroscience (NIN), Human genetics, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Reproduction & Development (AR&D), Pediatric surgery, Tedja, Milly S [0000-0003-0356-9684], Hysi, Pirro G [0000-0001-5752-2510], Verhoeven, Virginie JM [0000-0001-7359-7862], Iglesias, Adriana I [0000-0001-5532-764X], Tompson, Stuart W [0000-0001-9788-6730], Khawaja, Anthony P [0000-0001-6802-8585], Yamashiro, Kenji [0000-0001-9354-8558], Wedenoja, Juho [0000-0002-6155-0378], Jonas, Jost B [0000-0003-2972-5227], Wang, Ya Xing [0000-0003-2749-7793], Foster, Paul J [0000-0002-4755-177X], Klein, Ronald [0000-0002-4428-6237], Shah, Rupal L [0000-0001-8789-8869], Hayward, Caroline [0000-0002-9405-9550], Rudan, Igor [0000-0001-6993-6884], Wilson, James F [0000-0001-5751-9178], Joshi, Peter K [0000-0002-6361-5059], Whisenhunt, Kristina N [0000-0003-2412-7666], Rivadeneira, Fernando [0000-0001-9435-9441], Biino, Ginevra [0000-0002-9936-946X], Gharahkhani, Puya [0000-0002-4203-5952], Williams, Katie M [0000-0003-4596-3938], Delcourt, Cécile [0000-0002-2099-0481], Bellenguez, Céline [0000-0002-1240-7874], Hewitt, Alex W [0000-0002-5123-5999], Baird, Paul N [0000-0002-1305-3502], Bailey-Wilson, Joan E [0000-0002-9153-2920], Young, Terri L [0000-0001-6994-9941], Guggenheim, Jeremy A [0000-0001-5164-340X], Hammond, Christopher J [0000-0002-3227-2620], Klaver, Caroline CW [0000-0002-2355-5258], Apollo - University of Cambridge Repository, Epidemiology, Ophthalmology, Clinical Genetics, Pathology, Internal Medicine, Graduate School, Human Genetics, Experimental Immunology, ANS - Complex Trait Genetics, ARD - Amsterdam Reproduction and Development |
Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Adult Male Cell type ResearchInstitutes_Networks_Beacons/MICRA In silico taittovirheet Genome-wide association study Retinal Pigment Epithelium Biology Blindness Polymorphism Single Nucleotide Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12] Article Retina White People 03 medical and health sciences HIGH-GRADE MYOPIA RETINAL-PIGMENT EPITHELIUM SEROTONIN PATHWAY GENES FORM-DEPRIVATION MYOPIA COMMON VARIANTS OCULAR GROWTH RETINITIS-PIGMENTOSA GENOTYPE IMPUTATION MISSENSE MUTATIONS DOPAMINE-RECEPTORS Asian People refractive errors Retinitis pigmentosa Genetics medicine Myopia Journal Article Humans Genetic Predisposition to Disease 610 Medicine & health Regulation of gene expression Retinal pigment epithelium medicine.disease Refractive Errors 030104 developmental biology medicine.anatomical_structure Manchester Institute for Collaborative Research on Ageing Gene Expression Regulation genetic factors Eye disorder Female sense organs geneettiset tekijät Neuroscience Genome-Wide Association Study Signal Transduction |
Zdroj: | Nature Genetics, 50(6), 834-848. Nature Publishing Group CREAM Consortium 2018, ' Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error ', Nature Genetics, vol. 50, no. 6, pp. 834-848 . https://doi.org/10.1038/s41588-018-0127-7 the 23 and Me Research Team & Tedja, M S 2018, ' Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error ', Nature Genetics, vol. 50, no. 6, pp. 834-848 . https://doi.org/10.1038/s41588-018-0127-7 Nature Genetics, 50, 834-848 Nature genetics Tedja, M S, Wojciechowski, R, Hysi, P, Eriksson, N, Furlotte, N A, Verhoeven, V J M, Iglesias, A I, Meester-Smoor, M A, Khawaja, A P, Cheng, C Y, Horn, R, Yamashiro, K, Wenocur, A, Grazal., C, Haller, T, Metspalu, A, Wedenoja, J, Jonas, J B, Wang, Y X, Mitchell, P, Hammond, C, Klaver, C C W, Consortium, T CREAM, Research Team & Eye and Vision Consortium, UK B 2018, ' Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error ', Nature Genetics, vol. 50, no. 6, pp. 834-848 . https://doi.org/10.1038/s41588-018-0127-7 Tedja, M S, Wojciechowski, R, Hysi, P G, Eriksson, N, Furlotte, N A, Verhoeven, V J M, Iglesias, A I, Meester-Smoor, M A, Tompson, S W, Fan, Q, Khawaja, A P, Cheng, C-Y, Höhn, R, Yamashiro, K, Wenocur, A, Grazal, C, Haller, T, Metspalu, A, Wedenoja, J, Jonas, J B, Wang, Y X, Xie, J, Mitchell, P, Foster, P J, Klein, B E K, Klein, R, Paterson, A D, Hosseini, S M, Shah, R L, Williams, C, Teo, Y Y, Tham, Y C, Gupta, P, Zhao, W, Shi, Y, Saw, W-Y, Tai, E-S, Sim, X L, Huffman, J E, Polašek, O, Hayward, C, Bencic, G, Rudan, I, Wilson, J F, Joshi, P K, Tsujikawa, A, Matsuda, F, Whisenhunt, K N & Zeller, T & Vitart, V 2018, ' Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error ', Nature Genetics, vol. 50, pp. 834-848 . https://doi.org/10.1038/s41588-018-0127-7 Nature Genetics, 50, 6, pp. 834-848 Nat. Genet. 50, 834-848 (2018) Nature Genetics CREAM, 23andMe Research Team, UK Biobank Eye and Vision Consortium, Aslam, T M & Bishop, P N 2018, ' Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error ', Nature Genetics, vol. 50, no. 6, pp. 834-848 . https://doi.org/10.1038/s41588-018-0127-7 Nature genetics, 50(6), 834-848. Nature Publishing Group |
ISSN: | 1061-4036 |
Popis: | Skin affections after sulfur mustard (SM) exposure include erythema, blister formation and severe inflammation. An antidote or specific therapy does not exist. Anti-inflammatory compounds as well as substances counteracting SM-induced cell death are under investigation. In this study, we investigated the benzylisoquinoline alkaloide berberine (BER), a metabolite in plants like berberis vulgaris, which is used as herbal pharmaceutical in Asian countries, against SM toxicity using a well-established in vitro approach. Keratinocyte (HaCaT) mono-cultures (MoC) or HaCaT/THP-1 co-cultures (CoC) were challenged with 100, 200 or 300 mM SM for 1 h. Post-exposure, both MoC and CoC were treated with 10, 30 or 50 mu M BER for 24 h. At that time, supernatants were collected and analyzed both for interleukine (IL) 6 and 8 levels and for content of adenylate-kinase (AK) as surrogate marker for cell necrosis. Cells were lysed and nucleosome formation as marker for late apoptosis was assessed. In parallel, AK in cells was determined for normalization purposes. BER treatment did not influence necrosis, but significantly decreased apoptosis. Anti-inflammatory effects were moderate, but also significant, primarily in CoC. Overall, BER has protective effects against SM toxicity in vitro. Whether this holds true should be evaluated in future in vivo studies. |
Databáze: | OpenAIRE |
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