Loss of REM sleep features across nighttime in REM sleep behavior disorder

Autor: Smaranda Leu-Semenescu, Marie Vidailhet, Dario Arnaldi, Alice Latimier, Isabelle Arnulf
Přispěvatelé: CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Neuroradiologie [CHU Pitié-Salpêtrière], HAL-UPMC, Gestionnaire
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Adult
Male
Chronobiotic
Polysomnography
REM Sleep Behavior Disorder
Chronobiology Disorders
REM sleep behavior disorder
Non-rapid eye movement sleep
Tonic (physiology)
RBD
Melatonin
03 medical and health sciences
0302 clinical medicine
medicine
Humans
[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Circadian rhythm
Aged
Sleep Stages
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
medicine.diagnostic_test
Electromyography
Medicine (all)
musculoskeletal
neural
and ocular physiology
Circadian
Parkinson Disease
General Medicine
Middle Aged
medicine.disease
030104 developmental biology
Anesthesia
PD
Female
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Psychology
030217 neurology & neurosurgery
psychological phenomena and processes
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
medicine.drug
Zdroj: Sleep Medicine
Sleep Medicine, 2016, 17, pp.134-137. ⟨10.1016/j.sleep.2015.10.019⟩
Sleep Medicine, Elsevier, 2016, 17, pp.134-137. ⟨10.1016/j.sleep.2015.10.019⟩
ISSN: 1389-9457
DOI: 10.1016/j.sleep.2015.10.019⟩
Popis: Objectives Melatonin is a chronobiotic treatment which also alleviates rapid eye movement (REM) sleep behavior disorder (RBD). Because the mechanisms of this benefit are unclear, we evaluated the clock-dependent REM sleep characteristics in patients with RBD, whether idiopathic (iRBD) or associated with Parkinson's Disease (PD), and we compared findings with PD patients without RBD and with healthy subjects. Methods An overnight videopolysomnography was performed in ten iRBD patients, ten PD patients with RBD (PD + RBD+), ten PD patients without RBD (PD + RBD−), and ten controls. The rapid eye movement frequency per minute (REMs index), the tonic and phasic electromyographic (EMG) activity of the levator menti muscle, and the duration of each REM sleep episode were evaluated. A generalized linear model was applied in each group, with the REM sleep cycle (four ordinal levels) as the dependent variable, as a function of REMs index, REM sleep duration, and tonic and phasic EMG activity. Results From the first to the fourth sleep cycle, REM sleep duration progressively increased in controls only, REMs index increased in subjects without RBD but not in patients with RBD, whether idiopathic or associated with PD, whereas tonic and phasic EMG activity did not change. Conclusions Patients with PD or iRBD lost the physiologic nocturnal increase in REM sleep duration, and patients with RBD (either with or without PD) lost the increase of REMs frequency across the night, suggesting an alteration in the circadian system in RBD. This supports the hypothesis of a direct effect of melatonin on RBD symptoms by its chronobiotic activity.
Databáze: OpenAIRE
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