Cognitive Impairment In Treatment-Naïve Bipolar II and Unipolar Depression
| Autor: | Suzanne Ho-wai So, Sheila L. Y. Wong, Domily Ting Yi Lau, C. M. Leung, Alicia K. W. Chan, Linda Lam, Arthur D. P. Mak, Sing Lee, Owen Leung |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Psychosis Bipolar I disorder Bipolar Disorder lcsh:Medicine Neuropsychological Tests behavioral disciplines and activities Severity of Illness Index Article 03 medical and health sciences Bipolar II disorder Executive Function Young Adult 0302 clinical medicine Memory mental disorders medicine Humans Attention Cognitive Dysfunction Bipolar disorder lcsh:Science Depressive Disorder Major Multidisciplinary business.industry lcsh:R Cognitive flexibility Cognition medicine.disease 030227 psychiatry Case-Control Studies Major depressive disorder lcsh:Q Female Verbal memory business 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018) |
| ISSN: | 2045-2322 |
| Popis: | Cognition dysfunction may reflect trait characteristics of bipolarity but cognitive effects of medications have confounded previous comparisons of cognitive function between bipolar II and unipolar depression, which are distinct clinical disorders with some overlaps. Therefore, we examined the executive function (WCST), attention, cognitive speed (TMT-A) and memory (CAVLT, WMS-Visual reproduction) of 20 treatment-naïve bipolar II patients (BPII), 35 treatment-naïve unipolar depressed (UD) patients, and 35 age/sex/education matched healthy controls. The subjects were young (aged 18–35), and had no history of psychosis or substance use, currently depressed and meeting either RDC criteria for Bipolar II Disorder or DSM-IV-TR criteria for Major Depressive Disorder. The patients were moderately depressed (MADRS) and anxious(HAM-A), on average within 3.44 years of illness onset. Sociodemographic data and IQ were similar between the groups. UD patients had significantly slower cognitive speed and cognitive flexibility (WCST perseverative error). BPII depressed patients showed relatively intact cognitive function. Verbal memory (CAVLT List A total) correlated with illness chronicity only in BPII depression, but not UD. In conclusion, young and treatment-naïve BPII depressed patients differed from unipolar depression by a relatively intact cognitive profile and a chronicity-cognitive correlation that suggested a stronger resemblance to Bipolar I Disorder than Unipolar Depression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|