Promising results of surgical management of advanced medication related osteonecrosis of the jaws using adjunctive leukocyte and platelet rich fibrin
| Autor: | Alper Sindel, Göksel Şimşek Kaya, Burak Kocabalkan, Canan Öztürk, Öznur Özalp, Mehmet Ali Altay, Nelli Yıldırımyan |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Fistula Medication-related osteonecrosis of the jaw Platelet-Rich Fibrin medicine Humans Adjunctive therapy Ostectomy Stage (cooking) Dental Care General Dentistry Aged Aged 80 and over Wound Healing Surgical treatment business.industry Research Medical record Osteonecrosis RK1-715 Middle Aged medicine.disease Curettage Platelet-rich fibrin Leukocyte and platelet rich fibrin Surgery Jaw Sequestrectomy Platelet concentrates Dentistry Oral and maxillofacial surgery Bisphosphonate-Associated Osteonecrosis of the Jaw Female business |
| Zdroj: | BMC Oral Health, Vol 21, Iss 1, Pp 1-9 (2021) BMC Oral Health |
| ISSN: | 1472-6831 |
| Popis: | Background Leukocyte- and platelet-rich fibrin (L-PRF) is an autologous matrix scaffold which regulates inflammation by stimulating cytokines and growth factors that are involved in the immune response. L-PRF is suggested as a viable adjunctive method to surgical interventions due to its advantages on tissue healing. This study aims to retrospectively evaluate the adjunctive role of L-PRF in surgically treated medication-related osteonecrosis of the jaws (MRONJ) patients. Methods Between January 2012 and December 2020, patients with AAOMS stage II and III MRONJ lesions, who were treated surgically with adjunctive use of L-PRF in the authors’ institution were enrolled. Surgical interventions consisted of either marginal resection or sequestrectomy with peripheral ostectomy (SPO) or curettage and L-PRF application. Medical records of these patients were retrospectively reviewed and healing was assessed according to certain parameters including mucosal closure and presence of infection, exposed bone, fistula or radiologic markers of disease progression for a minimum of 12 months. Results Thirteen patients (7 women and 6 men) with an average age of 72.4 years (± 10.61, range 54–84) were included in the study, nine of whom had AAOMS stage III and four stage II MRONJ. Three patients had a marginal resection, nine patients had sequestrectomy with peripheral ostectomy (SPO) and one patient underwent a curettage procedure. All marginal resection and six SPO patients showed complete healing while four patients, who had SPO or curettage experienced incomplete healing. Mean follow up was 20.1 ± 18.29 months. Conclusion The use of L-PRF may be a favorable adjunctive option in the treatment of MRONJ owing to its favorable effects on tissue repair, ease of application, minimally invasive and cost-effective character and autogenous nature. Trial registration Retrospectively registered. |
| Databáze: | OpenAIRE |
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