Hypercalcemia in a patient with cholangiocarcinoma: a case report
| Autor: | Athanasios Zilos, Konstantinos Evangelou, Ioannis D. Xynos, Gregorios Hatzis, Stavros Sougioultzis |
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| Rok vydání: | 2009 |
| Předmět: |
Medicine(all)
lcsh:R5-920 medicine.medical_specialty business.industry General surgery Case Report General Medicine Malignancy medicine.disease Bioinformatics digestive system eye diseases digestive system diseases 3. Good health 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Medicine public health Medicine 030211 gastroenterology & hepatology sense organs lcsh:Medicine (General) business neoplasms hormones hormone substitutes and hormone antagonists |
| Zdroj: | International Archives of Medicine International Archives of Medicine, Vol 2, Iss 1, p 35 (2009) |
| ISSN: | 1755-7682 |
| Popis: | Background Humoral hypercalcemia of malignancy is rarely associated with cholangiocarcinoma (CC). Case report A 77-year-old man was admitted with confusion. Computer tomography showed a large multinodular mass in the right lobe of the liver and smaller lesions in the right lung. Liver histology confirmed the diagnosis of CC. Elevated calcium levels and suppressed intact parathyroid hormone in the absence of skeletal metastases or parathyroid gland pathology suggested the diagnosis of humoral hypercalcemia of malignancy (HHM). Treatment of hypercalcemia with saline infusion, loop diuretics, biphosphonate and calcitonin was effective in normalizing calcium levels and consciousness state within 48 hours, but a relapse occurred 4 weeks later and the patient succumbed to his disease. Conclusion Clinicians should be aware of this rare manifestation of CC as prompt and aggressive correction of hypercalcemia alleviates symptoms and improves patient's quality of life, despite the poor overall prognosis. |
| Databáze: | OpenAIRE |
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