Epigenetic inheritance, epimutation, and the response to selection
| Autor: | Robert E. Furrow |
|---|---|
| Přispěvatelé: | Hadany, Lilach |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Evolutionary Processes
Heredity General Science & Technology Population Population Modeling lcsh:Medicine Biology Epigenesis Genetic Genetic Models Genetic model Genetic variation Evolutionary Modeling Natural Selection Genetics Animals Allele Selection Genetic education lcsh:Science Selection Selection (genetic algorithm) education.field_of_study Evolutionary Biology Evolutionary Theory Multidisciplinary Natural selection Models Genetic Human Genome lcsh:R Biology and Life Sciences Computational Biology Genetic Variation Heritability Genetics Population Epigenetics lcsh:Q Genetic assimilation Population Genetics Epigenesis Research Article |
| Zdroj: | PLoS ONE, Vol 9, Iss 7, p e101559 (2014) PLoS ONE PloS one, vol 9, iss 7 |
| ISSN: | 1932-6203 |
| Popis: | There has been minimal theoretical exploration of the role of epigenetic variation in the response to natural selection. Using a population genetic model, I derive formulae that characterize the response of epigenetic variation to selection over multiple generations. Unlike genetic models in which mutation rates are assumed to be low relative to the strength of selection, the response to selection decays quickly due to a rapid lowering of parent-offspring epiallelic correlation. This effect is separate from the slowing response caused by a reduction in epigenetic variation. These results suggest that epigenetic variation may be less responsive to natural selection than is genetic variation, even in cases where levels of heritability appear similar. |
| Databáze: | OpenAIRE |
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