Micro-injection moulding of poly(vinylpyrrolidone-vinyl acetate) binary and ternary amorphous solid dispersions
| Autor: | John G. Lyons, Michael Hopkins Jnr, Romina Pezzoli, Noel M. Gately, Clement L. Higginbotham, Guillaume Direur |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
poly(vinylpyrrolidone-vinyl acetate)
Materials science Injection moulding Indomethacin lcsh:RS1-441 Pharmaceutical Science 02 engineering and technology 030226 pharmacology & pharmacy Article Class II drugs lcsh:Pharmacy and materia medica 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine indomethacin micro-injection moulding Vinyl acetate Dissolution testing Solubility Dissolution continuous processing class II drugs Poly(vinylpyrrolidone-vinyl acetate 021001 nanoscience & nanotechnology Controlled release 6. Clean water Amorphous solid Drug delivery systems chemistry Chemical engineering Materials Research Institute AIT Extrusion amorphous solid dispersions 0210 nano-technology Amorphous solid dispersions |
| Zdroj: | Pharmaceutics Volume 11 Issue 5 Pharmaceutics, Vol 11, Iss 5, p 240 (2019) |
| Popis: | Micro-injection moulding (µ IM) was used for the production of enteric tablets of plasticised and unplasticised solid dispersions of poly(vinylpyrrolidone-vinyl acetate) (PVPVA), and the effect of the mechanical and thermal treatment on the properties of the dispersions was investigated. The physical state of the systems showed to be unaltered by the µ IM step, maintaining the drug in the amorphous state. The dissolution profile of the tablets showed a slower dissolution rate due to the lower surface to volume ratio compared to the extruded strands. The lack of solubility of the doses in the acidic medium as a consequence of the acidity of indomethacin (IND) was observed. However, in neutral pH the drug dissolution showed slower rates without affecting the dissolution extent, showing a potential application for the development of controlled release doses. Overall, the production of tablets of amorphous solid dispersions (ASD), coupling hot-melt extrusion (HME) and µ IM, proved to be a successful approach towards a continuous automated manufacturing process to improve the aqueous solubility of poorly water-soluble drugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|