Factors associated with primary and secondary graft failure following cadaveric kidney transplant*
| Autor: | Irit Nave, Inbal Weiss-Salz, Micha Mandel, Geoffrey Boner, Noya Galai, Elisheva Simchen, Richard Nakache, Eytan Mor |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Time Factors Tissue and Organ Procurement Risk Factors Cadaver medicine Humans Organ donation Risk factor Intraoperative Complications Retrospective Studies Analysis of Variance Transplantation Univariate analysis business.industry Medical record Graft Survival Age Factors Retrospective cohort study HLA-DR Antigens Middle Aged medicine.disease Kidney Transplantation Tissue Donors Surgery Exact test Logistic Models Treatment Outcome surgical procedures operative Histocompatibility Multivariate Analysis Tissue and Organ Harvesting business Follow-Up Studies Kidney disease |
| Zdroj: | Clinical Transplantation. 18:571-575 |
| ISSN: | 1399-0012 0902-0063 |
| DOI: | 10.1111/j.1399-0012.2004.00228.x |
| Popis: | The risk profile for primary renal graft failure is largely unknown because of its inclusion with secondary failures or its exclusion from analysis. This study compares characteristics of the cadaveric transplant recipients who experienced primary failure, secondary failures or survived with a functioning graft for at least 6 months. Medical records of all cadaveric kidney-transplant patients performed in Israel over a 3-yr period 1997-2000 were reviewed. Fisher's exact test and multinomial regression models were used to assess the association of demographic, pre-operative and operative risk factors with the two types of failure outcomes. Of 325 grafts, 54 (16.6%) failed of which half were primary failures. Univariate analysis demonstrated a significant trend of increasing proportion of patients with specific risk factors from the functioning grafts group to the secondary and to the primary graft failure groups. Independent risk factors for primary graft failure included 'surgical complications', 'donor's age > or =60 yr', 'waiting for transplant > or =6 yr', and 'human leukocyte antigen-DR (HLA-DR) mismatch', based on the multivariate model. These factors may reflect the scarcity of organ donations in Israel, which leads to a prolonged waiting time, higher tolerance for HLA-DR mismatches, and utilization of kidneys from elderly donors. |
| Databáze: | OpenAIRE |
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