1-Boc-Piperidine-4-Carboxaldehyde Prevents Binge-Eating Behaviour and Anxiety in Rats
Autor: | Priscila Vázquez-León, Bruno A. Marichal-Cancino, Sergio Guzmán-Rodríguez, Jesús Chávez-Reyes, Melvin N. Rosalez, Gonzalo Allende, Marvin A. Soriano-Ursúa |
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Rok vydání: | 2021 |
Předmět: |
Elevated plus maze
medicine.drug_class Pain Context (language use) Anxiety Molecular Dynamics Simulation Pharmacology Ligands Weight Gain Anxiolytic Receptors G-Protein-Coupled chemistry.chemical_compound medicine Animals Rats Wistar Behavior Animal Dose-Response Relationship Drug Binge eating Feeding Behavior General Medicine Molecular Docking Simulation chemistry Mechanism of action Receptors Serotonin Wakefulness Piperidine medicine.symptom Energy Intake Binge-Eating Disorder Injections Intraperitoneal Stress Psychological Protein Binding |
Zdroj: | Pharmacology. 106:305-315 |
ISSN: | 1423-0313 0031-7012 |
Popis: | Background: Piperidines are biogenic amines studied mainly in toxicology because they were initially found as alkaloids from peppers and insect venoms. Piperidines are also produced in the human body, and their actions seem to be related to wakefulness/sleep and other cognitive phenomena. Piperidines have been minimally characterized for therapeutic applications. In this context, 1-Boc-piperidine-4-carboxaldehyde (1-Boc-piperidine) is a piperidine-derivative molecule with no mechanism of action reported, although its uses include the synthesis of GPR119 selective agonists that have been patented as anti-obesity drugs. Objectives: The aim of this work was to study the effects of 1-Boc-piperidine on binge-eating behaviour and anxiety in Wistar rats. Methods: In experimental protocol 1, binge-eating behaviour was induced in animals that received pre-treatment (i.p.) with (i) vehicle (methanol 10%; 1 mL/kg), (ii) 1-Boc-piperidine (1 µmol kg−1), or (iii) 1-Boc-piperidine (10 µmol kg−1). In experimental protocol 2, mildly stressed animals were evaluated in the elevated plus maze under the acute effects of the pre-treatments applied in experimental protocol 1. Results and Conclusions: 1-Boc-piperidine decreased, in a dose-dependent manner, the intake of calories from a succulent hyper-caloric food in a binge-eating protocol in female rats, whereas the acute exposition to this piperidine exerted an anxiolytic effect in the male rat. In both effects, the mechanism of action remains to be characterized. |
Databáze: | OpenAIRE |
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