A prospective study for prevalence and/or development of transfusion-transmitted infections in multiply transfused thalassemia major patients
| Autor: | Priti Desai, U. Chudgar, Nabajyoti Choudhury, Roopam Jain, Anil Khatri, Jim Perkins, Susan T. Johnson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
HBsAg
medicine.medical_specialty Thalassemia Virus Internal medicine medicine Immunology and Allergy Seroprevalence Prospective cohort study biology seroprevalence business.industry Human immunodeficiency virus lcsh:RC633-647.5 Hematology Hepatitis C β-thalassemia major lcsh:Diseases of the blood and blood-forming organs Hepatitis B medicine.disease Immunology biology.protein Original Article Antibody hepatitis C business |
| Zdroj: | Asian Journal of Transfusion Science, Vol 6, Iss 2, Pp 151-154 (2012) Asian Journal of Transfusion Science |
| ISSN: | 1998-3565 0973-6247 |
| Popis: | Objective: To evaluate the rate of seropositivity to hepatitis B and C and Human Immunodeficiency Virus (HIV) infections among children with β-thalassemia major receiving multiple transfusions in Ahmedabad, India, compared with healthy controls. Materials and Methods: The study was performed during January 2007 to January 2009 on multi-transfused children suffering with β-thalassemia major registered in the Prathama Blood Centre, Ahmedabad; Jeevandeep hospital, Ahmedabad; and Red Cross Blood Centre, Ahmedabad, and investigated for the prevalence and development of transfusion-transmitted infections. Hepatitis B surface Antigen (HBsAg), anti-Hepatitis C Virus (HCV) Antibodies (Ab), and HIV Ab were checked using a fourth-generation Enzyme-Linked Immunosorbent Assay (ELISA). Positive tests were confirmed by western blots. Healthy blood donors were used for the control group. Results: Hepatitis B surface antigen, anti-HCV Ab, and HIV Ab were positive in one of 96 (1.04%; 95% Confidence Interval (CI) = 0.17-1.3), 24 of 96 (25%; 95% CI = 11.4-14.2), and one of 96 (1.04%; 95% CI = 0.12-1.3), respectively. The rate of anti-HCV Ab was significantly higher in multi-transfused children suffering with β-thalassemia major. In thalassemia patients, the rate of positive anti-HCV Ab was significantly higher than that for positive HBsAg (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|