The spread of chloramphenicol-resistant Neisseria meningitidis in Southeast Asia
| Autor: | Somsavanh Sihalath, David A. B. Dance, Verena I. Carrara, Elizabeth M. Batty, Wanitda Watthanaworawit, Sona Soeng, Tomas-Paul Cusack, Janjira Thaipadungpanit, Paul Turner, Clare L. Ling, Jill Hopkins |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Microbiology (medical) Lineage (genetic) Tetracycline 030106 microbiology Chloramphenicol Resistance Neisseria meningitidis Biology Serogroup Antimicrobial resistance medicine.disease_cause Genome Article lcsh:Infectious and parasitic diseases Southeast asia Microbiology 03 medical and health sciences 0302 clinical medicine Drug Resistance Multiple Bacterial medicine Humans lcsh:RC109-216 030212 general & internal medicine Child Asia Southeastern Phylogeny 030304 developmental biology 0303 health sciences Phylogenetic tree 030306 microbiology Chloramphenicol Infant Newborn Infant Genomics General Medicine Middle Aged 3. Good health Penicillin Ciprofloxacin Infectious Diseases Child Preschool Female medicine.drug |
| Zdroj: | International Journal of Infectious Diseases International Journal of Infectious Diseases, Vol 95, Iss, Pp 198-203 (2020) |
| ISSN: | 1201-9712 |
| DOI: | 10.1101/2019.12.13.872499 |
| Popis: | Highlights • Chloramphenicol resistant strains of Neisseria meningitidis are present in three countries across Southeast Asia. • These strains are all closely related to each other and to resistant strains previously observed in Vietnam and France. • This lineage has acquired other antimicrobial resistance genes during its spread. Objectives Invasive disease caused by Neisseria meningitidis is a significant health concern globally, but our knowledge of the prevailing serogroups, antimicrobial susceptibility patterns, and genetics of N. meningitidis in Southeast Asia is limited. Chloramphenicol resistance in N. meningitidis has rarely been reported, but was first described in isolates from Vietnam in 1998. We aimed to characterise eight chloramphenicol resistant meningococcal isolates collected between 2007 and 2018 from diagnostic microbiology laboratories in Cambodia, Thailand and the Lao People's Democratic Republic (Laos). Methods Whole-genome sequencing was used to generate genome sequences from 18 meningococcal isolates including the eight chloramphenicol resistant isolates. We identified antimicrobial resistance genes present in these strains, and examined the phylogenetic relationships between strains. Results The eight resistant strains all contain the same chloramphenicol resistance gene first described in 1998, and are closely related to each other. Strains resistant to penicillin, tetracycline, and ciprofloxacin were also observed, including a chloramphenicol-resistant strain which has acquired penicillin and ciprofloxacin resistance. Conclusions This study suggests that chloramphenicol-resistant N. meningitidis is more widespread than previously thought, and that the previously-identified resistant lineage is now found in multiple countries in Southeast Asia. |
| Databáze: | OpenAIRE |
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