Ovulation-inducing drugs: a drug utilization and risk study in the Dutch population
| Autor: | H. Wesseling, A.C.A. Bortolussi, L. T. W. De Jong-Van Den Berg, Martina C. Cornel, R.E. Lappöhn, PB van den Berg, H.M. Twerda |
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| Rok vydání: | 1992 |
| Předmět: |
endocrine system
medicine.medical_specialty medicine.drug_class media_common.quotation_subject medicine.medical_treatment Population Human chorionic gonadotropin Clomifene medicine education Ovulation media_common Gynecology education.field_of_study In vitro fertilisation business.industry Obstetrics Health Policy Public Health Environmental and Occupational Health General Medicine Buserelin Ovulation induction Gonadotropin business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | International Journal of Risk and Safety in Medicine. 3:99-111 |
| ISSN: | 0924-6479 |
| DOI: | 10.3233/jrs-1992-3205 |
| Popis: | This study describes the use of the ovulation stimulating drugs clomifene, human chorionic gonadotropin (hCG) and human menopausal gonadotropin (hMG) in a representative sample of a population of Dutch women in the child-bearing age group. Clomifene or hMG/hCG are seldom used alone. A considerable percentage of the women received at least four different ovulation-inducing and related drugs during the observation period of two years. Thirty percent of the women who used clomifene were treated for 6 or more cycles. These findings argue for a relative "overuse" and "misuse" of clomifene. Buserelin, a drug not registered for the indication ovulation induction in The Netherlands but used in in vitro fertilization (IVF) programs as inhibitors of pituitary gonadotropin production, was nevertheless prescribed to 38% of the hMG /hCG users and to 11 % of the clomifene users. Our study indicates that, though the potential risks of congenital malformations due to clomifene are difficult to assess, they may be considerable; this, and the fact that different ovulation-inducing drugs are used together with clomifene, emphasizes the need for post-marketing surveillance. |
| Databáze: | OpenAIRE |
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