| Autor: |
Peter J Halfmann, Nicholas R Minor, Luis A Haddock III, Robert Maddox, Gage K Moreno, Katarina M Braun, David A Baker, Kasen K Riemersa, Ankur Prasad, Kirsten J Alman, Matthew C Lambert, Kelsey Florek, Allen Bateman, Ryan Westergaard, Nasia Safdar, David R Andes, Yoshihiro Kawaoka, Madiha Fida, Joseph D Yao, Thomas C Friedrich, David H O’Connor |
| Rok vydání: |
2022 |
| Předmět: |
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| DOI: |
10.1101/2022.04.11.22272784 |
| Popis: |
Prolonged infections in immunocompromised individuals may be a source for novel SARS-CoV-2 variants, particularly when both the immune system and antiviral therapy fail to clear the infection and enable within-host evolution. Here we describe a 486-day case of SARS-CoV-2 infection in an immunocompromised individual. Following monotherapy with the monoclonal antibody Bamlanivimab, the individual’s virus acquired resistance, likely via the earliest known occurrence of Spike amino acid variant E484T. Recently, E484T has arisen again as a derivative of E484A in the Omicron Variant of Concern, supporting the hypothesis that prolonged infections can give rise to novel variants long before they become prevalent in the human population. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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