Safety and immunogenicity of a combined DTPa–IPV vaccine administered as a booster from 4 years of age: A review
| Autor: | Jm Jacquet, Stephen B. Lambert, Giacomo Faldella, Sa Silfverdal, Peter Richmond, Emmanuel Grimprel, Terry Nolan, Philippe Reinert, Lode Schuerman, Don Roberton, Synne Sandbu, P Bégué, Helen Marshall |
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| Přispěvatelé: | Jacquet JM, Bégué P, Grimprel E, Reinert P, Sandbu S, Silfverdal SA, Faldella G, Nolan T, Lambert S, Richmond P, Marshall H, Roberton D, Schuerman L. |
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
BOOSTER VACCINATION VACCINE-ASSOCIATED ADVERSE EVENTS animal diseases Immunization Secondary VACCINE Booster dose IMMUNOGENICITY Antibodies Viral Diphtheria-Tetanus-acellular Pertussis Vaccines medicine.disease_cause complex mixtures Gastroenterology Antigen Internal medicine medicine Humans Vaccines Combined Child Whooping cough General Veterinary General Immunology and Microbiology Tetanus business.industry Diphtheria Poliovirus Immunogenicity Public Health Environmental and Occupational Health respiratory system medicine.disease Antibodies Bacterial Surgery Poliovirus Vaccine Inactivated Infectious Diseases ACELLULAR PERTUSSIS Child Preschool Toxicity cardiovascular system Molecular Medicine business circulatory and respiratory physiology |
| Zdroj: | Vaccine. 24:2440-2448 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2005.12.009 |
| Popis: | A combined DTPa-IPV booster vaccine was administered as a 4th or 5th dose after DTPa or DTPw priming. Over 99% vaccines developed antibody levels considered to be protective to diphtheria, tetanus and poliovirus, and >95% mounted a response to acellular pertussis antigens. Rectal temperature >39.5 degrees C was observed in at most 3.2% of vaccinees. Swelling >50 mm occurred in 24% of DTPa-primed compared to 5.5% of DTPw-primed children. Large swelling involving the entire upper arm (extending to involve the elbow joint) was reported for up to 1.2% of DTPa-primed subjects, which is consistent with literature reports for other DTPa vaccines. |
| Databáze: | OpenAIRE |
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