Antihypertensive effects of DL-tetrahydropalmatine: an active principle isolated from Corydalis
| Autor: | CF Chen, FY Chueh, MT Hsieh, Mao-Tsun Lin |
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| Rok vydání: | 1996 |
| Předmět: |
Agonist
Bradycardia Male medicine.medical_specialty Physiology medicine.drug_class Microdialysis Berberine Alkaloids Blood Pressure Serotonergic Rats Inbred WKY Rats Sprague-Dawley Dopamine Heart Rate Physiology (medical) Internal medicine Rats Inbred SHR medicine Animals Antihypertensive Agents Pharmacology Analysis of Variance Dose-Response Relationship Drug Chemistry Amphetamines Receptor antagonist Rats Serotonin Receptor Agonists Apomorphine Monoamine neurotransmitter Endocrinology cardiovascular system Serotonin Ketanserin Serotonin Antagonists medicine.symptom Hypotension medicine.drug |
| Zdroj: | Clinical and experimental pharmacologyphysiology. 23(8) |
| ISSN: | 0305-1870 |
| Popis: | 1. The effects of DL-tetrahydropalmatine (DL-THP) on cardio-vascular function and hypothalamic release of monoamines were assessed in rats under urethane anaesthesia. 2. Intravenous administration of DL-THP (1-10 mg/kg) produced hypotension, bradycardia, a decrease in hypothalamic serotonin and noradrenaline release and an increase in hypothalamic dopamine release in rats. 3. Intrahypothalamic administration of DOI (a serotonergic 5-HT2 receptor antagonist) or apomorphine (a dopamine D2-receptor agonist) produced the opposite effects and reversed DL-THP-induced hypotension and bradycardia. 4. The data suggest that DL-THP acts through the 5-HT2 and/or D2-receptor antagonism in the hypothalamus to induce hypotension and bradycardia in rats. |
| Databáze: | OpenAIRE |
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