Effects of bilingualism on age at onset in two clinical Alzheimer's disease variants
| Autor: | Maria Luisa Gorno-Tempini, Maya L. Henry, Wendy Shwe, Stephanie M. Grasso, Zachary A. Miller, Gil D. Rabinovici, Bruce L. Miller, Ariane E. Welch, Jessica De Leon |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Aging Epidemiology Multilingualism Disease Neuropsychological Tests Neurodegenerative Audiology Alzheimer's Disease California Primary progressive aphasia 0302 clinical medicine Cognitive Reserve Age of Onset Neuroscience of multilingualism Cognitive reserve Health Policy 05 social sciences Middle Aged Psychiatry and Mental health Neurological Cohort Female psychological phenomena and processes medicine.medical_specialty multilingualism Primary Progressive Clinical Sciences behavioral disciplines and activities Article 050105 experimental psychology 03 medical and health sciences Cellular and Molecular Neuroscience Developmental Neuroscience Alzheimer Disease Clinical Research Aphasia Acquired Cognitive Impairment medicine Humans Dementia 0501 psychology and cognitive sciences Symptom onset Retrospective Studies business.industry Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) bilingualism medicine.disease Brain Disorders Aphasia Primary Progressive Geriatrics primary progressive aphasia Neurology (clinical) Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Zdroj: | Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 12 Alzheimers Dement |
| ISSN: | 1552-5279 1552-5260 |
| Popis: | Introduction The effect of bilingualism on age at onset has yet to be examined within different clinical variants of Alzheimer's disease. Methods We reviewed the research charts of 287 well-characterized participants with either amnestic Alzheimer's dementia or logopenic variant primary progressive aphasia (lvPPA) and identified bilingual speakers based on regular use of two or more languages and/or ability to communicate with native speakers in two or more languages. We evaluated whether bilingual speakers demonstrated a delay in age of symptom onset relative to monolingual speakers while controlling for other variables known to influence cognitive reserve. Results A 5-year delay in age at symptom onset was observed for bilingual relative to monolingual speakers with lvPPA. This delay in onset was not observed in the amnestic Alzheimer's dementia cohort. Discussion Bilingualism may serve as a unique cognitive reserve variable in lvPPA, but not in amnestic Alzheimer's dementia. |
| Databáze: | OpenAIRE |
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