Muscular hydraulics drive larva-polyp morphogenesis
| Autor: | Anniek Stokkermans, Aditi Chakrabarti, Kaushikaram Subramanian, Ling Wang, Sifan Yin, Prachiti Moghe, Petrus Steenbergen, Gregor Mönke, Takashi Hiiragi, Robert Prevedel, L. Mahadevan, Aissam Ikmi |
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| Přispěvatelé: | Hubrecht Institute for Developmental Biology and Stem Cell Research |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Life Sciences & Biomedicine - Other Topics
Biochemistry & Molecular Biology Science & Technology SEA METAMORPHOSIS MECHANOTRANSDUCTION SEGMENTATION TISSUE MORPHOGENESIS ANEMONE NEMATOSTELLA-VECTENSIS Cell Biology General Biochemistry Genetics and Molecular Biology Sea Anemones DIFFERENTIATION Larva Morphogenesis Animals AXIS General Agricultural and Biological Sciences Life Sciences & Biomedicine Biology SETTLEMENT GENERATION |
| Zdroj: | Current Biology, 32(21), 4707-4718.e8. Cell Press |
| ISSN: | 0960-9822 |
| Popis: | Development is a highly dynamic process in which organisms often experience changes in both form and behavior, which are typically coupled to each other. However, little is known about how organismal-scale behaviors such as body contractility and motility impact morphogenesis. Here, we use the cnidarian Nematostella vectensis as a developmental model to uncover a mechanistic link between organismal size, shape, and behavior. Using quantitative live imaging in a large population of developing animals, combined with molecular and biophysical experiments, we demonstrate that the muscular-hydraulic machinery that controls body movement also drives larva-polyp morphogenesis. We show that organismal size largely depends on cavity inflation through fluid uptake, whereas body shape is constrained by the organization of the muscular system. The generation of ethograms identifies different trajectories of size and shape development in sessile and motile animals, which display distinct patterns of body contractions. With a simple theoretical model, we conceptualize how pressures generated by muscular hydraulics can act as a global mechanical regulator that coordinates tissue remodeling. Altogether, our findings illustrate how organismal contractility and motility behaviors can influence morphogenesis. ispartof: CURRENT BIOLOGY vol:32 issue:21 pages:4707-+ ispartof: location:England status: published |
| Databáze: | OpenAIRE |
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