Association of polymorphisms of dopamine D2 receptor (DRD2), and dopamine transporter (DAT1) genes with schizoid/avoidant behaviors (SAB)
| Autor: | A A Pontius, N Schnautz, W Walsh, M Sherman, D Matthews, J G Cull, S. Wu, L Fischer, K Blum, A Eisenberg, D E Comings, T J H Chen, Eric R. Braverman, R Wood, G Kaats, M Zedar, Janusz Gill, K R Davis |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Schizoid Personality Disorder Nerve Tissue Proteins Developmental psychology Cellular and Molecular Neuroscience Dopamine receptor D3 Internal medicine Dopamine receptor D2 medicine Humans Allele Molecular Biology Gene Pathological Dopamine transporter Dopamine Plasma Membrane Transport Proteins Membrane Glycoproteins Polymorphism Genetic biology Receptors Dopamine D2 business.industry Mental Disorders Dopaminergic Membrane Transport Proteins Middle Aged Psychiatry and Mental health Endocrinology Dopamine receptor Schizophrenia biology.protein Female Carrier Proteins business |
| Zdroj: | Molecular Psychiatry. 2:239-246 |
| ISSN: | 1476-5578 1359-4184 |
| DOI: | 10.1038/sj.mp.4000261 |
| Popis: | The dopaminergic system, and in particular the dopamine D2 receptor, has been implicated in reward mechanisms in the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance-seeking behaviors (ethanol, drugs, tobacco, and food) and other related behaviors (pathological gambling, Tourette's disorder, attention-deficit/hyperactivity disorder). This is the first study supporting a strong association between the dopamine D2 receptor Taq A1 allele with schizoid/avoidant behavior (SAB). Additionally, an albeit weaker association between the 480-bp VNTR 10/10 allele of the dopamine transporter (DAT1) gene with SAB was similarly found. |
| Databáze: | OpenAIRE |
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