In vitro fertilization for women infected by hepatitis C virus: a matched case-control study and a systematic literature review
Autor: | Chloë Shaw-Jackson, Lieveke Ameye, Jean Vandromme, Yannick Manigart, Candice Autin, Mélissa Capraro, Serge Rozenberg |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Adult
medicine.medical_specialty Pregnancy Rate Hepatitis C virus medicine.medical_treatment Reproductive medicine Fertilization in Vitro Hepacivirus medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Pregnancy Internal medicine Genetics medicine Humans Embryo Implantation Pregnancy Complications Infectious Assisted Reproduction Technologies Genetics (clinical) 030219 obstetrics & reproductive medicine In vitro fertilisation business.industry Case-control study Obstetrics and Gynecology General Medicine medicine.disease Hepatitis C Systematic review Reproductive Medicine 030220 oncology & carcinogenesis Case-Control Studies Immunology Female General health business Developmental Biology |
Popis: | The aim of this study was to investigate whether infection of women by the hepatitis C virus (HCV) reduces the chance of conceiving after in vitro fertilization (IVF). We performed a retrospective blind matched case-control study where IVF outcomes for the first 37 cycles of HCV sero-positive women were compared to those of 107 cycles of an uninfected control group. Our results were included in a systematic literature review. Out of five eligible studies, ours included, three observed an impact of HCV infection, though at various levels including response to stimulation, fertilization, implantation, and pregnancy rates. Two studies differentiated results for patients with confirmed active viral replication. Matching criteria and populations studied varied between studies. More and larger studies with well-defined groups are needed to clarify the eventual impact of the HCV on IVF outcomes. Data concerning the infectious status of a patient as well as her health state should be systematically recorded. A multi-disciplinary approach as well as a thorough knowledge of the patient’s general health state might prove useful in the management and counseling of these patients in terms of success in conceiving. |
Databáze: | OpenAIRE |
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