| Autor: |
Chang-Sheng Zhang, Fu-Min Zhang, Jin-Xin Zhu, Xiao-Ming Zhang, Yong-Qiang Tu, Ming Yang, Li-Xin Shan, Xue Han, Hong Wang, Wen-Shuo Zhang |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Angewandte Chemie (International ed. in English). 60(42) |
| ISSN: |
1521-3773 |
| Popis: |
Although copper-nitrene has been extensively studied as a versatile active species in various transformations, asymmetric reactions involving copper-nitrene have been limited to the aziridination of olefins. Herein, we report the novel copper-nitrene-catalyzed desymmetric oxaziridination reaction of cyclic diketones with alkyl azides and the subsequent rearrangement of the resulting highly active intermediate, which produces a synthetically challenging chiral bicyclic lactam containing a quaternary carbon center. This procedure not only enriches the copper-nitrene-catalyzed asymmetric reactions, but also provides an alternative strategy to address the inherent challenges of catalytic asymmetric Schmidt reactions. This unique reaction could inspire the investigation of novel copper-nitrene-catalyzed asymmetric transformations and their reaction mechanisms. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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