The potential effects of introducing microneedle patch vaccines into routine vaccine supply chains
| Autor: | Bvudzai Priscilla Magadzire, Jim Leonard, Emmanuelle Assy, Jenn Bakal, Patrick T. Wedlock, Ruth Bechtel, Joel Welling, Sheryl S. Siegmund, Shawn T. Brown, Fayad Elsheikh, Elizabeth A. Mitgang, Bruce Y. Lee, Jay V. DePasse, Jessica Crawford |
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| Rok vydání: | 2019 |
| Předmět: |
Modeling software
Microinjections Supply chain 030231 tropical medicine India Transdermal Patch medicine.disease_cause Article Toxicology 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Vaccine administration Refrigeration Rotavirus Tetanus Toxoid medicine Benin Humans 030212 general & internal medicine Cold chain Mozambique Vaccines General Veterinary General Immunology and Microbiology Immunization Programs Tetanus business.industry Vaccination Rotavirus Vaccines Public Health Environmental and Occupational Health Toxoid medicine.disease Infectious Diseases Influenza Vaccines Costs and Cost Analysis Molecular Medicine business |
| Zdroj: | Vaccine. 37:645-651 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2018.12.008 |
| Popis: | BACKGROUND: Microneedle patch (MNP) technology is designed to simplify the process of vaccine administration; however, depending on its characteristics, MNP technology may provide additional benefits beyond the point-of-use, particularly for vaccine supply chains. METHODS: Using the HERMES modeling software, we examined replacing four routine vaccines – Measles-containing vaccine (MCV), Tetanus toxoid (TT), Rotavirus (Rota) and Pentavalent (Penta) – with MNP versions in the routine vaccine supply chains of Benin, Bihar (India), and Mozambique. RESULTS: Replacing MCV with an MNP (5 cm(3)-per-dose, 2-month thermostability, current single-dose price-per-dose) improved MCV availability by 13%, 1% and 6% in Benin, Bihar and Mozambique, respectively, and total vaccine availability by 1% in Benin and Mozambique, while increasing the total cost per dose administered by $0.07 in Benin, $0.56 in Bihar and $0.11 in Mozambique. Replacing TT with an MNP improved TT and total vaccine availability (3% and |
| Databáze: | OpenAIRE |
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