Predisposing genetic factors for diabetic polyneuropathy in patients with type 1 diabetes: a population-based case-control study
Autor: | T. R. Bursa, O. I. Drepa, I. A. Strokov, Valery V. Nosikov, E. V. Zotova, Ametov As |
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Rok vydání: | 2004 |
Předmět: |
Adult
medicine.medical_specialty Diabetic neuropathy Adolescent Genotype SOD3 Endocrinology Diabetes and Metabolism SOD2 medicine.disease_cause Polymorphism Single Nucleotide White People Russia Endocrinology Diabetic Neuropathies Risk Factors Internal medicine Diabetes mellitus Internal Medicine Genetic predisposition Medicine Humans Genetic Predisposition to Disease Child Glycated Hemoglobin Type 1 diabetes business.industry Smoking Case-control study General Medicine Middle Aged medicine.disease Diabetes Mellitus Type 1 Case-Control Studies business Oxidative stress |
Zdroj: | Acta diabetologica. 40 |
ISSN: | 0940-5429 |
Popis: | Oxidative stress plays a key role in the development of microvascular complications of diabetes mellitus (DM). Antioxidant enzymes protect against the rapid onset of diabetic polyneuropathy (DPN) by reducing oxidative stress. Genetic variations that affect activity or expression levels of the antioxidant enzymes may therefore be associated with susceptibility to DPN. We examined polymorphic markers Ala(-9)Val in SOD2 gene and Arg213Gly in SOD3 gene for possible relation to DPN in Russian type 1 diabetic patients. Four hundred Russian white patients with type 1 diabetes were studied using neurological examination according to recommendations of the San Antonio Conference on Diabetic Neuropathy. Two groups were formed from the general sample. Definition of frequency distribution of the polymorphic markers was performed in these groups using the polymerase chain reaction. Genes encoding the enzymes Mn-SOD and extracellular superoxide dismutase (EC-SOD) were found to be associated with the pathogenesis of DPN. |
Databáze: | OpenAIRE |
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