rhBMP in lumber fusion for lumbar spondylolisthesis: A systematic review and meta-analysis
| Autor: | Pengcui Li, Lei Wei, Xiao-Dong Li, Pengfei Han, Zhi-Liang Zhang, Taoyu Chen, Xiaochun Wei, Zhi Lü |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Time Factors Spondylolysis Cochrane Library Iliac crest law.invention Ilium 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Statistical significance Bone morphogenetic proteins medicine Humans Orthopedics and Sports Medicine Autografts Lumbar spondylolisthesis Randomized Controlled Trials as Topic lcsh:R5-920 030222 orthopedics Lumbar Vertebrae business.industry 030208 emergency & critical care medicine medicine.disease Databases Bibliographic Recombinant Proteins Surgery Meta-analysis medicine.anatomical_structure Spinal Fusion Treatment Outcome Sample size determination Systematic Review and Meta-analysis Spondylolisthesis lcsh:Medicine (General) business |
| Zdroj: | Chinese Journal of Traumatology Chinese Journal of Traumatology, Vol 22, Iss 1, Pp 51-58 (2019) |
| ISSN: | 1008-1275 |
| Popis: | Purpose: To compare the efficacy and safety of recombinant human bone morphogenetic protein (rhBMP) and iliac crest autograft in the fusion treatment of lumbar spondylolisthesis. Methods: The studies using randomized controlled trials to compare the rhBMP with iliac crest autograft in the treatment of lumbar spondylolisthesis were retrieved from Embase, Pubmed, ProQuest dissertations & theses (PQDT), China national knowledge infrastructure (CNKI), Chinese Biomedical Database, Wanfang Data, Cochrane Library (from March 1998 to March 2018). Postoperative fusion rate, clinical success rate, postoperative intervertebral height, complications, operation time, blood loss and duration of hospitalization were chosen as the outcome indicators. Methodological quality of the trials was critically assessed, and relevant data were extracted. Statistical software Revman 5.3 was used for data-analysis. Results: Eleven articles were included in the meta-analysis. The results showed that, comparing the efficacy of rhBMP with iliac crest autograft, statistical significance was found in the 24-month fusion rate post operation [95% CI (1.38, 24.70), p ＝0.02] and operation time [95% CI (-14.22, -2.08), p ＝0.008]. There is not sufficient evidence for statistical differences in the remaining indicators. Conclusion: The current literature shows rhBMP is a safe and effective grafting material in the treatment of lumbar spondylolisthesis. Further evidence is dependent on the emergence of more randomized controlled trials with higher quality and larger sample sizes in the future. Key words: Spondylolysis; Bone morphogenetic proteins; Ilium; Autografts; Meta-analysis |
| Databáze: | OpenAIRE |
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