Association of the thyroglobulin gene polymorphism with autoimmune thyroid disease in Chinese population
| Autor: | Wan-xia Xiao, Jin-an Zhang, Ying Quan, Mai Maierhaba, Zhi-yun Yu, Yu Wang, Bao-ning Dong |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Graves' disease medicine.medical_treatment Single-nucleotide polymorphism Hashimoto Disease Polymorphism Single Nucleotide Thyroglobulin Thyroiditis Young Adult Endocrinology Asian People Gene Frequency Polymorphism (computer science) Internal medicine Humans Medicine Genetic Predisposition to Disease Allele frequency business.industry Haplotype Middle Aged medicine.disease Graves Disease Genotype frequency Haplotypes Case-Control Studies Female business Polymorphism Restriction Fragment Length |
| Zdroj: | Endocrine. 33:294-299 |
| ISSN: | 1559-0100 1355-008X |
| DOI: | 10.1007/s12020-008-9082-x |
| Popis: | Objective This study was performed to identify the presence of previously reported thyroglobulin (Tg) gene single nucleotide polymorphisms (SNPs) in Han Chinese Asians, and to investigate their potential relation to autoimmune thyroid disease (AITD). Methods Polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) in 228 Chinese patients with AITD (146 with Graves’ disease and 82 with Hashimoto’s thyroiditis) and 131 healthy Chinese controls. Results (1) The occurrence of four common Tg gene SNPs (E10SNP24 T/G and E10SNP158 T/C in exon 10, E12SNP A/G in exon 12, and E33SNP C/T in exon 33) was confirmed in this Chinese population. No differences in allele and genotype frequencies were found between AITD patients and control subjects, or between male and female individuals in any group. Neither were differences in allele frequencies observed when Graves’ disease (GD) or Hashimoto’s thyroiditis (HT) patients were analyzed separately. (2) Haplotype analysis of these four SNPs revealed that the G-C-A-C haplotype was significantly associated with HT (P |
| Databáze: | OpenAIRE |
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