Peripheral γδ T Cell Receptor-Bearing Lymphocytes Are Increased in Children with Celiac Disease
| Autor: | Emma M. Savilahti, Timo Klemola, T Ormälä, J Tarkkanen, H Saxen |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Pathology medicine.medical_specialty Adolescent Lymphocyte Receptors Antigen T-Cell Epithelium Coeliac disease Flow cytometry Leukocyte Count 03 medical and health sciences 0302 clinical medicine Antigen medicine Humans Lymphocytes Intestinal Mucosa Child Gamma delta T cell 030304 developmental biology chemistry.chemical_classification 0303 health sciences Lamina propria medicine.diagnostic_test business.industry T-cell receptor Gastroenterology nutritional and metabolic diseases medicine.disease Gluten Lymphocyte Subsets digestive system diseases 3. Good health Celiac Disease Jejunum medicine.anatomical_structure chemistry Pediatrics Perinatology and Child Health Immunology Female business 030215 immunology |
| Zdroj: | Journal of Pediatric Gastroenterology and Nutrition. 18:435-439 |
| ISSN: | 0277-2116 |
| DOI: | 10.1097/00005176-199405000-00005 |
| Popis: | The percentages of gamma delta T cell receptor-bearing (TCR+) cells in the peripheral blood and jejunal mucosa of patients with celiac disease were measured before treatment, during a gluten free-diet, and after a gluten challenge. The percentages of the different cell types were evaluated by flow cytometry, and immunohistochemical staining of the jejunal specimen was used to identify lymphocyte surface markers. Nineteen blood samples and intestinal specimens from 13 children with celiac disease (eight samples taken before treatment, six during gluten-free diet, and five after gluten challenge) and samples from nine controls were studied. The proportion of gamma delta TCR+ lymphocytes was significantly higher both in the peripheral blood and the jejunal mucosa of the patients with celiac disease. A significant correlation was found between the percentage of peripheral gamma delta TCR+ cells and the density of gamma delta TCR+ cells in the lamina propria. |
| Databáze: | OpenAIRE |
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