Development and validation a novel preoperative comprehensive prognostic score based on inflammatory and nutritional score, coagulation indicator and tumor marker in esophageal squamous cell carcinoma
| Autor: | Qixun Chen, Xun Yang, Ji-Feng Feng, Liang Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Medicine (General) business.industry squamous cell carcinoma antigen General Medicine Nomogram Fibrinogen Squamous cell carcinoma Antigen Esophageal squamous cell carcinoma Prognostic score esophageal squamous cell carcinoma c-reactive protein to albumin ratio stomatognathic diseases R5-920 Internal medicine Medicine fibrinogen Neutrophil to lymphocyte ratio business High group neutrophil to lymphocyte ratio medicine.drug Tumor marker |
| Zdroj: | Bosnian Journal of Basic Medical Sciences (2021) |
| Popis: | We herein propose a novel integrative score based on inflammatory and nutritional score, coagulation indicator and tumor marker, named comprehensive prognostic score (CPS), to predict postoperative survival in resectable esophageal squamous cell carcinoma (ESCC). We also aimed to establish and validate a nomogram based on CPS and other clinical features for individual survival prediction. A total of 490 resectable ESCC patients were randomly divided into either a training or validation cohort at a ratio of 7:3 for retrospective analysis. The CPS, based on squamous cell carcinoma antigen (SCCA), C-reactive protein to albumin ratio (CAR), neutrophil to lymphocyte ratio (NLR), and fibrinogen (FIB), was divided into two models to verify its prognostic value. The predictive model of CPS-based nomogram was established and validated in two cohorts. Patients with CPS low group in model 1 had better 5-year cancer-specific survival (CSS) than those in CPS high group (50.7% vs. 17.8%, P |
| Databáze: | OpenAIRE |
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