Studies of Monoclonal Antibodies Specific for Major Histocompatibility Complex Products of the Rat
| Autor: | Hans Binz, M. Fenner, Winterhalter K, C. Binder, Wigzell H, Hemmi S |
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| Rok vydání: | 2006 |
| Předmět: |
medicine.drug_class
T-Lymphocytes Immunology Major histocompatibility complex Monoclonal antibody Rats Mutant Strains Immune system Immunoglobulin Idiotypes Antigen Antibody Specificity Histocompatibility Antigens Rats Inbred BN medicine Animals Immunosorbent Techniques biology Antibodies Monoclonal General Medicine Virology Antibodies Anti-Idiotypic Rats Rats Inbred Lew Polyclonal antibodies biology.protein Anti-idiotypic antibodies Immunization Rabbits Antibody |
| Zdroj: | Scandinavian Journal of Immunology. 21:565-573 |
| ISSN: | 0300-9475 |
| DOI: | 10.1111/j.1365-3083.1985.tb01846.x |
| Popis: | Polyclonal anti-idiotypic antibodies against monoclonal antibodies with specificity for RT1-encoded antigens were induced in syngeneic, allogeneic, and xenogeneic hosts. The immune response to the idiotypic determinants on monoclonal antibodies was T-cell-dependent. The anti-idiotypic antibodies, independent of whether they were induced in syngeneic, allogeneic, or xenogeneic (after proper absorption) hosts, showed an exquisite specificity for the monoclonal antibody used for the induction. No cross-reactivity with other monoclonal antibodies could be observed. |
| Databáze: | OpenAIRE |
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