Regioselective Sonogashira cross-coupling reactions of 6-chloro-2,8-diiodo-9-THP-9H-purine with alkyne derivatives
| Autor: | Nada Ibrahim, Franciane Chevot, Michel Legraverend |
|---|---|
| Přispěvatelé: | Marie, Nathalie, Conception, synthèse et vectorisation de biomolécules. (CSVB), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris], Institut Curie-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
chemistry.chemical_classification
Purine 010405 organic chemistry Stereochemistry [CHIM.ORGA]Chemical Sciences/Organic chemistry Organic Chemistry Regioselectivity Alkyne Sonogashira coupling 010402 general chemistry [CHIM.ORGA] Chemical Sciences/Organic chemistry 01 natural sciences Biochemistry Combinatorial chemistry Coupling reaction 0104 chemical sciences chemistry.chemical_compound chemistry Derivative (finance) Drug Discovery Purine derivative Purine metabolism ComputingMilieux_MISCELLANEOUS |
| Zdroj: | Tetrahedron Letters Tetrahedron Letters, Elsevier, 2011, 52, pp.305-307 |
| ISSN: | 0040-4039 |
| Popis: | Lithiation of 6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine with LiTMP, gave access to 6-chloro-2,8-dihalogenated purine derivatives. In particular, the 6-chloro-2,8-diiodopurine derivative is an interesting new intermediate which gave regioselectively various 2-alkynylated compounds or 2,8-dialkynylated purines by using an excess of alkyne. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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