ESR Study on the Structure and Hydroxyl Radical-Scavenging Activity Relationships of Ginsenosides Isolated from Panax ginseng C. A. MEYER
| Autor: | Hyun Young Kim, Noriko Yamabe, Jeong Hill Park, Ki Sung Kang, Takako Yokozawa |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Pharmacology
Sapogenins Antioxidant Ginsenosides Molecular Structure Hydroxyl Radical Stereochemistry Chemistry medicine.medical_treatment Electron Spin Resonance Spectroscopy Active components Panax Pharmaceutical Science Free Radical Scavengers General Medicine Medicinal chemistry Ferrous Structure-Activity Relationship Ginseng chemistry.chemical_compound Electron spin resonance spectrometer Aglycone medicine Hydroxyl radical Scavenging |
| Zdroj: | Biological and Pharmaceutical Bulletin. 30:917-921 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.30.917 |
| Popis: | Ginsenosides have been regarded as the main active components of Panax ginseng C. A. MEYER, and the an- tioxidant activity of ginsenosides in vivo is well described. However, there has been virtually no report describing the direct free radical-scavenging activities of ginsenosides through the long history of ginseng research. The hy- droxyl radical ( · OH)-scavenging activity test using an electron spin resonance spectrometer (ESR) is suggested to be the most appropriate to measure the antioxidant activities of ginsenosides. Therefore, we investigated the · OH-scavenging and ferrous metal ion-chelating activities of several ginsenosides of Panax ginseng using ESR for the identification of active ginsenosides and its structure and activity relationships. As a result, 20(S)-Rg3 showed the strongest activity, and the next were in the decreasing order of Rb 1 , Rg 1 , Rc, Rb 2 , and Rd when dissolved with water. The · OH-scavenging activities of ginsenosides were related to the ferrous metal ion-chelating activities of their aglycone, 20(S)-protopanaxadiol. In addition, the ferrous metal ion-chelating activities of ginsenosides were thought to be influenced by their types of hydrophilic sugar moieties. |
| Databáze: | OpenAIRE |
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