Examination of retinal vascular density changes via optical coherence tomography angiography in patients with glaucoma
| Autor: | Berire Şeyma Durmuş Ece, Murat Sinan Sarıcaoğlu |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Intraocular pressure genetic structures Nerve fiber layer Glaucoma chemistry.chemical_compound Nerve Fibers Optical coherence tomography Ophthalmology medicine Humans Intraocular Pressure medicine.diagnostic_test business.industry Retinal Vessels Retinal medicine.disease eye diseases Confidence interval medicine.anatomical_structure chemistry Angiography Optic nerve sense organs business Microvascular Density Glaucoma Open-Angle Tomography Optical Coherence |
| Zdroj: | International ophthalmology. 41(2) |
| ISSN: | 1573-2630 |
| Popis: | The aim of this study was to investigate the changes in vessel density (VD) in glaucoma patients and to investigate the relationship between VD and structural parameters using optical coherence tomography angiography. Our study included 25 primary open-angle glaucoma (POAG) patients, 25 pseudoexfoliation glaucoma (PXG) patients and 25 healthy individuals. All patients underwent 6 × 6 mm retinal angiography (upper limit: internal limitan membrane [ILM], lower limit: 10 µm inferior to inner plexiform layer) and 4.5 × 4.5 mm disk angiography (upper limit: ILM, lower limit: posterior border of the retinal nerve fiber layer [RNFL]) via an optical coherence tomography (OCT) system (AngioVue, Optovue). Measures of vascular density were as follows: total area VD (tVD), intrapapillary VD (iVD), peripapillary VD (pVD) and parafoveal VD (pfVD). In addition to performing comparisons, the correlations between pVD, retinal nerve fiber layer (RNFL) thickness and optic nerve head measurement results were investigated. A total of 75 individuals were included in our study. In the POAG and PXG groups, tVD and pVD values were significantly lower than the control group (median tVDs were: 45.4, 45.9, 50.0, and median pVDs were: 50.0, 50.3, 53.1, respectively) (confidence intervals were: − 9.8/− 1.1 for pVD and − 8.6/− 1.4 for tVD). Significantly lower pf-VD values were detected in the PXG group compared to the control group (p |
| Databáze: | OpenAIRE |
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