Future possibilities in the prevention of breast cancer: Luteinizing hormone-releasing hormone agonists

Autor: Darcy V. Spicer, Malcolm C. Pike
Jazyk: angličtina
Rok vydání: 2000
Předmět:
Pilot Projects
Gonadotropin-releasing hormone
Review
Gonadotropin-Releasing Hormone
Endometrium
Methyltestosterone
Multicenter Studies as Topic
Breast
Progesterone
Clinical Trials as Topic
Incidence
Goserelin
Estrogen Replacement Therapy
Neoplasms
Second Primary
medicine.anatomical_structure
Female
Luteinizing hormone
medicine.drug
Mammography
Risk
medicine.medical_specialty
endocrine system
medicine.drug_class
Ovariectomy
Ovary
Breast Neoplasms
Breast cancer
Internal medicine
medicine
Humans
Cancer prevention
business.industry
breast cancer prevention
Epithelial Cells
Estrogens
medicine.disease
Endocrinology
hormonal carcinogenesis
Premenopause
Estrogen
gonadotropin-releasing hormone agnonists
Feasibility Studies
Osteoporosis
Progestins
business
Secretory Rate
Hormone
luteinizing hormone-releasing hormone agonists
Forecasting
Zdroj: Breast Cancer Research : BCR
ISSN: 1465-542X
1465-5411
Popis: The cyclic production of estrogen and progesterone by the premenopausal ovary accounts for the steep rise in breast cancer risk in premenopausal women. These hormones are breast cell mitogens. By reducing exposure to these ovarian hormones, agonists of luteinizing hormone-releasing hormone (LHRH) given to suppress ovarian function may prove useful in cancer prevention. To prevent deleterious effects of hypoestrogenemia, the addition of low-dose hormone replacement to the LHRH agonist appears necessary. Pilot data with such an approach indicates it is feasible and reduces mammographic densities.
Databáze: OpenAIRE
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