In vivo osseointegration and erosion of nacre screws in an animal model
| Autor: | Hélène Libouban, Jean-Daniel Kün-Darbois, Serge Camprasse, Daniel Chappard, Georges Camprasse |
|---|---|
| Přispěvatelé: | Groupe d'Études Remodelage Osseux et bioMatériaux (GEROM), Université d'Angers (UA) |
| Rok vydání: | 2020 |
| Předmět: |
Male
musculoskeletal diseases Materials science [SDV]Life Sciences [q-bio] Bone Screws Biomedical Engineering Dentistry chemistry.chemical_element 02 engineering and technology maxillofacial surgery Osseointegration Rats Sprague-Dawley Biomaterials Fracture Fixation Internal 03 medical and health sciences Animal model In vivo titanium screw Animals Femur Nacre 030304 developmental biology 0303 health sciences Osteosynthesis business.industry Significant difference Biomaterial erosion musculoskeletal system equipment and supplies 021001 nanoscience & nanotechnology Ostreidae Rats mother of pearl Disease Models Animal Trabecular bone surgical procedures operative chemistry resorbable device 0210 nano-technology business Titanium |
| Zdroj: | Journal of Biomedical Materials Research Part B: Applied Biomaterials Journal of Biomedical Materials Research Part B: Applied Biomaterials, Wiley, 2020, ⟨10.1002/jbm.b.34743⟩ |
| ISSN: | 1552-4981 1552-4973 |
| DOI: | 10.1002/jbm.b.34743 |
| Popis: | International audience; The use of resorbable devices for osteosynthesis has become a subject of interest. Nacre has been proposed as a resorbable and osteoconductive material favoring bone apposition without triggering an inflammatory reaction. We compared the in vivo osseointegration and erosion of nacre screws in an animal model with titanium screws. Implantation of similar nacre and titanium screws was performed in the femoral condyles of adult rats. Animals (n = 41) were randomized in four groups sacrificed at day one, 1, 6, and 12 months. Microcomputed tomography (microCT) allowed 3D morphometry of erosion of nacre. Osseointegration was measured as the volume of trabecular bone bone volume/tissue volume (BV/TV) in a standardized volume of interest around each screw. Undecalcified bone histol-ogy was also done. Gross examination revealed a similar clinical osseointegration for titanium and nacre screws. A progressive erosion of nacre screws, but no erosion of titanium screws, was observed in microCT. The volume of nacre screws progressively decreased over time whereas no modification occurred for titanium. For titanium screws, BV/TV remained stable throughout the study. For nacre screws, the BV/TV decrease was not statistically different. A significant difference was found between nacre and titanium screws at 6 months but not at 12 months. The screw heads, outside the bone shaft, were not eroded even after 12 months. Erosion of nacre occurred during the entire study period, only within the bone shaft in direct contact with bone marrow. Bone apposition was observed on nacre surfaces without signs of erosion. Nacre is a promising biomaterial in maxillofacial surgery. K E Y W O R D S erosion, maxillofacial surgery, mother of pearl, nacre, osseointegration, resorbable device, titanium screw |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text