Detection of 28 Corticosteroids in Pharmaceutical and Proprietary Chinese Medicinal Products Using Liquid Chromatography-Tandem Mass Spectrometry
Autor: | Candace Yim Chan, Chor Kwan Ching, Sau Wah Ng, Tony W L Mak |
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Rok vydání: | 2020 |
Předmět: |
Drug
medicine.medical_specialty China Drug Contamination medicine.drug_class media_common.quotation_subject Traditional Chinese medicine 030226 pharmacology & pharmacy 01 natural sciences Analytical Chemistry 03 medical and health sciences 0302 clinical medicine Liquid chromatography–mass spectrometry Adrenal Cortex Hormones Limit of Detection Tandem Mass Spectrometry Adrenal insufficiency medicine Humans Adverse effect Intensive care medicine media_common Chromatography Chemistry 010401 analytical chemistry General Medicine medicine.disease 0104 chemical sciences Pharmaceutical Preparations Corticosteroid Over-the-counter Chromatography Liquid |
Zdroj: | Journal of chromatographic science. 59(6) |
ISSN: | 1945-239X |
Popis: | With their potent anti-inflammatory effects, corticosteroids are popular adulterants in illicit health products for allergies, dermatitis and pain control. Their illegal supply over the counter is also a common practice for similar conditions. Prolonged, unsupervised usage of corticosteroids often leads to severe adverse effects including Cushing syndrome, adrenal insufficiency and immunosuppression. Confirming clinical suspicion of unsupervised corticosteroid usage is challenging. Apart from evaluating the adrenal function, identifying the concerned drug is the most direct proof of its consumption. While detecting corticosteroids or their metabolites in biological specimens is convincing evidence of their usage, such approach is analytically difficult. More importantly, this approach would not be useful if the patient has stopped taking the drug for some time—a situation that is often encountered clinically. We advocate a more direct approach by measuring corticosteroids in suspicious medicinal products. In the current study, a liquid chromatography–tandem mass spectrometry method for simultaneous detection of 28 corticosteroids in pharmaceutical and proprietary Chinese medicine products was developed and validated for the purpose. The method was applied to 388 cases of suspected unsupervised corticosteroids usage. Among 1,000 products tested, corticosteroids were found in 276 of them and confirmed the clinical suspicion. |
Databáze: | OpenAIRE |
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