Diffusion-weighted magnetic resonance imaging for pretreatment prediction and monitoring of treatment response of patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy
| Autor: | Line Brennhaug Nilsen, Oliver Geier, Therese Seierstad, Dag Rune Olsen, Anne Fangberget |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Treatment response medicine.medical_specialty Breast imaging medicine.medical_treatment Locally advanced Breast Neoplasms Breast cancer Predictive Value of Tests Antineoplastic Combined Chemotherapy Protocols medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies skin and connective tissue diseases Prospective cohort study Aged Chemotherapy medicine.diagnostic_test business.industry Magnetic resonance imaging Hematology General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Neoadjuvant Therapy body regions Treatment Outcome Oncology Chemotherapy Adjuvant Predictive value of tests Female Radiology business |
| Zdroj: | Acta Oncologica. 49:354-360 |
| ISSN: | 1651-226X 0284-186X |
| DOI: | 10.3109/02841861003610184 |
| Popis: | Background . For patients with locally advanced breast cancer (LABC) undergoing neoadjuvant chemotherapy (NACT), the European Guidelines for Breast Imaging recommends magnetic resonance imaging (MRI) to be performed before start of NACT, when half of the NACT has been administered and prior to surgery. This is the fi rst study addressing the value of flapparent diffusion coeffi cients (ADCs) obtained from diffusion-weighted (DW) MRI at the recommended time points for pretreatment prediction and monitoring of treatment response. Materials and methods . Twenty-fi ve LABC patients were included in this prospective study. DW MRI was performed using single-shot spin-echo echo-planar imaging with b-values of 100, 250 and 800 s/mm 2 prior to NACT, after four cycles of NACT and at the conclusion of therapy using a 1.5 T MR scanner. ADC in the breast tumor was calculated from each assessment. The strength of correlation between pretreatment ADC, ADC changes and tumor volume changes were examined using Spearman’s rho correlation test. Results . Mean pretreatment ADC was 1.11 � 0.21 � 10 � 3 mm 2 /s. After 4 cycles of NACT, ADC was signifi cantly increased (1.39 � 0.36 � 10 � 3 mm 2 /s; p� 0.018). There was no correlation between individual pretreatment breast tumor ADC and MR response measured after four cycles of NACT (p� 0.816) or prior to surgery (p� 0.620). Conclusion . Pretreatment tumor ADC does not predict treatment response for patients with LABC undergoing NACT. Furthermore, ADC increase observed mid-way in the course of NACT does not correlate with tumor volume changes. |
| Databáze: | OpenAIRE |
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