| Autor: |
Jerzy Kuch, Edmund Nartowicz, Andrzej Budaj, Janusz Maciejewicz, Wanda Śmielak-Korombel, Piotr Kokowicz, Teresa Zaleska, Leszek Ceremużyński, Maria Krzeminska-Pakula, Andrzej Dyduszyński |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Journal of the American College of Cardiology. 25(2) |
| ISSN: |
0735-1097 |
| DOI: |
10.1016/0735-1097(95)93128-y |
| Popis: |
The Polish Amiodarone Trial revealed significant reduction of l-year cardiac mortality with low-dose Amiodarone (Am) after MI. To assess whether this beneficial effect persisted, the long-term outcomes of the pts of the Am treated group (n = 305) and ofthe control group (C) (n = 309) were assessed. The probability of cardiac death after 12 and 46 months according to Kaplan-Meier curves was respectively Am 6.2,17.4% and C 10.7, 19.5%. The curves after 12 months remained parallel. The comparison of 25 pts treated continuosly for 46 months with Am and 189 C pts not treated with Am revealed significant difference in survival curves in favour of Am treated group (p = 0.04). Side effects occurred in 3 of 25 pts treated with Am during long-term follow-up. Beneficial effect of one year Am treatment on survival after Mi persists for the next three years. The prolongation of therapy is feasible and diminishes the risk of cardiac death. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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